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(3S)-β-homophenylalanine benzyl ester hydrochloride is a hydrochloride salt form of the amino acid derivative β-homophenylalanine benzyl ester, commonly used in the synthesis of pharmaceuticals and drugs. It has potential applications in the treatment of various medical conditions and diseases due to its ability to modulate and target specific biological pathways and processes. This promising chemical is a subject of research and study in the pharmaceutical and medical fields.
Used in Pharmaceutical Industry:
(3S)-β-homophenylalanine benzyl ester hydrochloride is used as a key intermediate in the synthesis of pharmaceuticals and drugs for its ability to modulate and target specific biological pathways and processes, contributing to the development of new treatments for various medical conditions and diseases.

1329063-33-3

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1329063-33-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1329063-33-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,2,9,0,6 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1329063-33:
(9*1)+(8*3)+(7*2)+(6*9)+(5*0)+(4*6)+(3*3)+(2*3)+(1*3)=143
143 % 10 = 3
So 1329063-33-3 is a valid CAS Registry Number.

1329063-33-3Relevant academic research and scientific papers

Targeting the prostaglandin f2α receptor for preventing preterm labor with azapeptide tocolytics

Bourguet, Carine B.,Goupil, Eugénie,Tassy, Dana?,Hou, Xin,Thouin, Eryk,Polyak, Felix,Hébert, Terence E.,Claing, Audrey,Laporte, Stéphane A.,Chemtob, Sylvain,Lubell, William D.

experimental part, p. 6085 - 6097 (2011/11/05)

The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2- one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased allosteric mechanism, involving both Gαq- and Gα12-mediated signaling pathways, and exhibited significant tocolytic activity delaying preterm labor in a mouse model (Goupil; et al.J. Biol. Chem. 2010, 285, 25624-25636). Although changes in azabicycloalkane stereochemistry and ring size caused loss of activity, replacement of the indolizidin-2-one amino acid with azaGly-Pro and azaPhe-Pro gave azapeptides 6 and 8, which reduced PGF2α-induced myometrial contractions, potentiated the effect of PGF2α on Gαq-mediated ERK1/2 activation, and inhibited FP modulation of cell ruffling, a response dependent on the Gα12/RhoA/ROCK signaling pathway. Revealing complementarities of azabicycloalkane and azapeptide mimics, novel probes, and efficient tocolytic agents were made to study allosteric modulation of the FP receptor.

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