Tacrine hydrochloride

Base Information

• Chemical Name: Tacrine hydrochloride
• CAS No.: 1684-40-8
• Molecular Formula: C13H15ClN2
• Molecular Weight: 234.728
• Hs Code.: 2933990090
• European Community (EC) Number: 216-867-5
• NSC Number: 759324,72108
• UNII: 4966RNG0BU
• DSSTox Substance ID: DTXSID1026112
• Wikidata: Q27259239
• NCI Thesaurus Code: C47742
• Pharos Ligand ID: 5L7ZPW8RPXA9
• ChEMBL ID: CHEMBL1677
• Mol file: 1684-40-8.mol

Synonyms:1,2,3,4-Tetrahydro-9-acridinamine;1,2,3,4-Tetrahydroaminoacridine;9-Amino-1,2,3,4-Tetrahydroacridine;Cognex;Romotal;Tacrine;Tacrine Hydrochloride;Tenakrin;Tetrahydroaminoacridine;THA

Chemical Property of Tacrine hydrochloride

Chemical Property:

• Appearance/Colour: pale yellow solid
• Vapor Pressure: 6.49E-07mmHg at 25°C
• Melting Point: 280-284 °C(lit.)
• Boiling Point: 409.4 °C at 760 mmHg
• PKA: pKa 9.8 (Uncertain)
• Flash Point: 230.5 °C
• PSA: 38.91000
• LogP: 4.07900
• Storage Temp.: 2-8°C
• Solubility.: Soluble in aqueous buffers
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 234.0923762
• Heavy Atom Count: 16
• Complexity: 229

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tacrine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xn
• Hazard Codes: T,Xn
• Statements: 25-36/37/38-20/22
• Safety Statements: 26-36-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
• Description: Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems. Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Formulations containing tacrine have been used clinically in the treatment of Alzheimer’s disease.
• Uses: anticholinesterase, cognitive adjuvant, K channel blocker A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.