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| CAS No.: | 1684-40-8 |
|---|---|
| Name: | TACRINE HYDROCHLORIDE |
| Molecular Structure: | |
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| Formula: | C13H15ClN2 |
| Molecular Weight: | 234.728 |
| Synonyms: | 9-Acridinamine,1,2,3,4-tetrahydro-, monohydrochloride (9CI);Acridine,9-amino-1,2,3,4-tetrahydro-, hydrochloride (7CI);9-Amino-1,2,3,4-Tetrahydroacridine hydrochloride;CI 970;Acridine,9-amino-1,2,3,4-tetrahydro-, monohydrochloride (8CI);1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride;5,6,7,8-Tetrahydroacridin-9-amine hydrochloride;Cognex;Hydroaminacrine;Romotal;THA;Tacrin hydrochloride;Tacrine hydrochloride;Tenakrin; |
| EINECS: | 216-867-5 |
| Melting Point: | 280-284 °C(lit.) |
| Boiling Point: | 409.4 °C at 760 mmHg |
| Flash Point: | 230.5 °C |
| Appearance: | pale yellow solid |
| Hazard Symbols: |
 T, Xn
|
| Risk Codes: | 25-36/37/38-20/22 |
| Safety: | 26-36-45 |
| PSA: | 38.91000 |
| LogP: | 4.07900 |
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Specification
The Tacrine hydrochloride, with the CAS registry number 1684-40-8, is also known as 9-Acridinamine, 1,2,3,4-tetrahydro-, monohydrochloride. It belongs to the product categories of Chemical Amines; Amines; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Acetylcholine Receptor. Its EINECS registry number is 216-867-5. This chemical's molecular formula is C13H15ClN2 and molecular weight is 234.7246. Its IUPAC name is called 1,2,3,4-tetrahydroacridin-9-amine hydrochloride. This chemical's classification codes are Cognition Adjuvant; Dementia Symptoms Treatment Adjunct; Drug / Therapeutic Agent; Mutation Data. A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. Tacrine hydrochloride also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi.
Physical properties of Tacrine hydrochloride: (1)ACD/LogP: 3.32; (2)ACD/LogD (pH 5.5): 0.85; (3)ACD/LogD (pH 7.4): 1.74; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 5.15; (6)ACD/KOC (pH 5.5): 5.25; (7)ACD/KOC (pH 7.4): 40.09; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Flash Point: 230.5 °C; (12)Enthalpy of Vaporization: 66.16 kJ/mol; (13)Boiling Point: 409.4 °C at 760 mmHg; (14)Vapour Pressure: 6.49E-07 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is toxic and harmful. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
(2)InChI: InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
(3)InChIKey: ZUFVXZVXEJHHBN-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 5600ug/kg (5.6mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07602, | |
| rat | LDLo | intramuscular | 40mg/kg (40mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 638, 1958. |