BUTTPARK 80\07-41

Base Information

• Chemical Name: BUTTPARK 80\07-41
• CAS No.: 874804-14-5
• Molecular Formula: C₇H₅BrClFO₂S
• Molecular Weight: 287.537
• Hs Code.: 2904909090
• Mol file: 874804-14-5.mol

Synonyms:BUTTPARK 80\07-41;4-Bromo-2-fluoro-5-methylbenzenesulfonyl chloride

Chemical Property of BUTTPARK 80\07-41

Chemical Property:

• PSA: 42.52000
• LogP: 3.90490

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-Fluoro-5-methylbenzene-1-sulfonylchloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 80\07-41

There total 2 articles about BUTTPARK 80\07-41 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-bromo-2-fluoro-5-methylaniline (418762-26-2) → 4-bromo-2-fluoro-5-methylbenzene-1-sulfonyl chloride (874804-14-5)

Guidance literature:

4-bromo-2-fluoro-5-methylaniline; With hydrogenchloride; In water; at 0 ℃; for 0.5h;

With sodium nitrite; In water; at 0 ℃; Further stages;

Reference yield:

2-bromo-4-fluorotoluene (1422-53-3) → 4-bromo-2-fluoro-5-methylbenzene-1-sulfonyl chloride (874804-14-5)

Guidance literature:

With chlorosulfonic acid; at 0 - 20 ℃; for 5h;

Reference yield:

4-bromo-2-fluoro-5-methylbenzene-1-sulfonyl chloride (874804-14-5) → 4-bromo-2-fluoro-N-(isothiazol-4-yl)-5-methyl-N-((2-(trimethylsilyl)ethoxy)methyl)benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; pyridine / dichloromethane / 12 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 40 °C

2.2: 12 h / 0 - 20 °C

With pyridine; dmap; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-2-fluoro-5-methylaniline

2-bromo-4-fluorotoluene

Refernces

• 1、 -. "BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS". Page/Page column 407-408. . Retrieved 2017/12/18.