418762-26-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-fluoro-5-methylaniline is used as a synthetic intermediate for the development of complex drug molecules. Its unique chemical structure allows for the creation of a variety of pharmaceutical compounds, contributing to the advancement of medicinal chemistry.
Used in Advanced Material Development:
In the field of material science, 4-Bromo-2-fluoro-5-methylaniline is employed as a building block in the synthesis of advanced materials. 4-Bromo-2-fluoro-5-methylaniline's reactivity and structural features make it a valuable component in the design and production of new materials with specialized properties.

InChI:InChI=1/C7H7BrFN/c1-4-2-7(10)6(9)3-5(4)8/h2-3H,10H2,1H3

Upstream product

• 452-84-6 3-amino-4-fluorotoluene 

Downstream Products

• 939968-22-6 1-(4-bromo-2-fluoro-5-methylphenyl)-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea 
• 1132944-97-8 N-(4-bromo-2-fluoro-5-methylphenyl)methanesulfonamide 
• 1202389-31-8 2-fluoro-5-methyl-4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)aniline 
• 1243246-11-8 2-fluoro-5-methyl-4-(2-methylpyridin-4-yl)aniline 
• 1332332-77-0 5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-[2-fluoro-5-methyl-4-(7-quinolinyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332333-77-3 N-(4-bromo-2-fluoro-5-methylphenyl)-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide 
• 1386951-27-4 N,N-dibenzyl-4-bromo-2-fluoro-5-methylbenzenamine 
• 1386951-28-5 tert-butyl 4-(4-(dibenzylamino)-5-fluoro-2-methylphenyl)piperazine-1-carboxylate 
• 1386951-29-6 tert-butyl 4-(4-amino-5-fluoro-2-methylphenyl)piperazine-1-carboxylate 
• 1390657-52-9 tert-butyl 4-(4-(7-chloro-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-5-fluoro-2-methylphenyl)piperazine-1-carboxylate 
• 1390657-53-0 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-5-fluoro-2-methylphenyl)piperazine-1-carboxylate 
• 1390655-92-1 7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one 
• 1202389-33-0 4-(5-fluoro-2-methyl-4-(4-(5-methyl-1H-pyrazol-3-ylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)phenyl)cyclohexanone 
• 1202389-32-9 2-fluoro-5-dimethyl-4-(1,4-dioxaspiro[4.5]decan-8-yl)aniline 

Relevant academic research and scientific papers

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.