N-(4-Aminophenyl)nicotinamide

Base Information

Chemical Name:N-(4-Aminophenyl)nicotinamide
CAS No.:19060-64-1
Molecular Formula:C12H11N3O
Molecular Weight:213.239
Hs Code.:
DSSTox Substance ID:DTXSID40360655
Wikidata:Q82142511
Mol file:19060-64-1.mol

Synonyms:N-(4-Aminophenyl)nicotinamide;19060-64-1;N-(4-Amino-phenyl)-nicotinamide;N-(4-aminophenyl)pyridine-3-carboxamide;SCHEMBL3093633;DTXSID40360655;BBL029684;MFCD02585681;STK497999;AKOS000100238;VS-09364;N-(4-aminophenyl)nicotinamide, AldrichCPR;BB 0217338;CS-0313260;FT-0677195;A880406

Suppliers and Price of N-(4-Aminophenyl)nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(4-aminophenyl)nicotinamide
100mg
$ 60.00

Matrix Scientific
N-(4-Amino-phenyl)-nicotinamide
1g
$ 278.00

Matrix Scientific
N-(4-Amino-phenyl)-nicotinamide
500mg
$ 181.00

Crysdot
N-(4-Aminophenyl)nicotinamide 95+%
5g
$ 787.00

Chemenu
N-(4-Aminophenyl)nicotinamide 95%
5g
$ 743.00

ChemBridge Corporation
N-(4-aminophenyl)nicotinamide 95%
5 g
$ 297.00

American Custom Chemicals Corporation
N-(4-AMINO-PHENYL)-NICOTINAMIDE 95.00%
5MG
$ 501.50

Alichem
N-(4-Aminophenyl)nicotinamide
5g
$ 826.80

Total 11 raw suppliers

Chemical Property of N-(4-Aminophenyl)nicotinamide

Chemical Property:

Vapor Pressure:0.000178mmHg at 25°C
Boiling Point:329.4°C at 760 mmHg
Flash Point:153°C
PSA：68.01000
Density:1.301g/cm³
LogP:2.57030
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:213.090211983
Heavy Atom Count:16
Complexity:236

Purity/Quality:

97% ^*data from raw suppliers

N-(4-aminophenyl)nicotinamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CN=C1)C(=O)NC2=CC=C(C=C2)N

Technology Process of N-(4-Aminophenyl)nicotinamide

There total 7 articles about N-(4-Aminophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 13160-62-8
N-(4-nitrophenyl)-3-pyridinecarboxamide

: 19060-64-1
N-(4-aminophenyl)-3-pyridinecarboxamide

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 6h;

Reference yield:

: 59-67-6
nicotinic acid

: 19060-64-1
N-(4-aminophenyl)-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

3: ammonium chloride; iron / water; ethanol / 6 h / Reflux

With thionyl chloride; iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c16-00154

Reference yield:

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 19060-64-1
N-(4-aminophenyl)-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 1.5 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/cmdc.201100168