3-(2-Hydroxyethyl)-N-(phenylmethyl)-4-pyridinecarboxamide

Base Information

• Chemical Name: 3-(2-Hydroxyethyl)-N-(phenylmethyl)-4-pyridinecarboxamide
• CAS No.: 345311-05-9
• Molecular Formula: C15H16N2O2
• Molecular Weight: 256.304
• Hs Code.: 2933399090
• Mol file: 345311-05-9.mol

Synonyms:4-pyridinecarboxamide, 3-(2-hydroxyethyl)-N-(phenylmethyl)-; N-Benzyl-3-(2-hydroxyethyl)isonicotinamide; N-benzyl-3-(2-hydroxyethyl)pyridine-4-carboxamide

Chemical Property of 3-(2-Hydroxyethyl)-N-(phenylmethyl)-4-pyridinecarboxamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 505.577°C at 760 mmHg
• Flash Point: 259.564°C
• PSA: 62.22000
• Density: 1.198g/cm³
• LogP: 1.93730

Purity/Quality:

99%min ^*data from raw suppliers

3-(2-HYDROXYETHYL)-N-(PHENYLMETHYL)-4-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Hydroxyethyl)-N-(phenylmethyl)-4-pyridinecarboxamide

There total 3 articles about 3-(2-Hydroxyethyl)-N-(phenylmethyl)-4-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

oxirane (75-21-8,99932-75-9) + isonicotinic acid benzylamide (6320-63-4) → N-benzyl-3-(2-hydroxyethyl)isonicotinamide (345311-05-9)

Guidance literature:

isonicotinic acid benzylamide; With n-butyllithium; In hexane; at -78 ℃; for 1h; Inert atmosphere;

oxirane; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.05.027

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) → N-benzyl-3-(2-hydroxyethyl)isonicotinamide (345311-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

2.1: n-butyllithium / hexane / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1016/j.bmc.2018.05.027

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → N-benzyl-3-(2-hydroxyethyl)isonicotinamide (345311-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 5 h / 50 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: n-butyllithium / hexane / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1016/j.bmc.2018.05.027

upstream raw materials:

oxirane

isonicotinic acid benzylamide

pyridine-4-carboxylic acid

4-(chlorocarbonyl)pyridine

Downstream raw materials:

6-benzyl-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine 2-oxide

Refernces

• 1、 -. "Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition". . . Retrieved 2008/06/13.