Ethyl 2,5-dichlorothiazole-4-carboxylate

Base Information

Chemical Name:Ethyl 2,5-dichlorothiazole-4-carboxylate
CAS No.:135925-33-6
Molecular Formula:C₆H₅Cl₂NO₂S
Molecular Weight:226.083
Hs Code.:2934100090
European Community (EC) Number:814-459-7
DSSTox Substance ID:DTXSID00568074
Nikkaji Number:J1.794.622F
Wikidata:Q82454223
Mol file:135925-33-6.mol

Synonyms:Ethyl 2,5-dichlorothiazole-4-carboxylate;135925-33-6;ETHYL 2,5-DICHLORO-1,3-THIAZOLE-4-CARBOXYLATE;MFCD16615250;2,5-Dichloro-thiazole-4-carboxylic acid ethyl ester;F2158-0660;SCHEMBL9861374;DTXSID00568074;AKOS015958328;Ethyl2,5-dichlorothiazole-4-carboxylate;DS-18027;SY108122;CS-0151812;EN300-217353;O11750;A846598

Suppliers and Price of Ethyl 2,5-dichlorothiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2,5-dichlorothiazole-4-carboxylate 95+%
5g
$ 891.00

Crysdot
Ethyl2,5-dichlorothiazole-4-carboxylate 95+%
1g
$ 287.00

Chemenu
Ethyl2,5-dichlorothiazole-4-carboxylate 95%
1g
$ 271.00

Chemenu
Ethyl2,5-dichlorothiazole-4-carboxylate 95%
5g
$ 842.00

Chemcia Scientific
2,5-Dichloro-thiazole-4-carboxylicacidethylester 95%
1 G
$ 295.00

American Custom Chemicals Corporation
ETHYL-2,5-DICHLOROTHIAZOLE-4-CARBOXYLATE 95.00%
5MG
$ 499.76

Alichem
Ethyl2,5-dichlorothiazole-4-carboxylate
1g
$ 480.25

Alichem
Ethyl2,5-dichlorothiazole-4-carboxylate
5g
$ 1318.23

AK Scientific
Ethyl2,5-dichlorothiazole-4-carboxylate
5g
$ 1265.00

Total 10 raw suppliers

Chemical Property of Ethyl 2,5-dichlorothiazole-4-carboxylate

Chemical Property:

Boiling Point:319.8±45.0 °C(Predicted)
PKA:-3.22±0.10(Predicted)
PSA：67.43000
Density:1.502±0.06 g/cm3(Predicted)
LogP:2.62660
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:224.9418050
Heavy Atom Count:12
Complexity:181

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2,5-dichlorothiazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC(=N1)Cl)Cl
Uses Ethyl 2,5-dichlorothiazole-4-carboxylate is used as a reactant in the preparation of halogenated thiazole isocyanates.

Technology Process of Ethyl 2,5-dichlorothiazole-4-carboxylate

There total 3 articles about Ethyl 2,5-dichlorothiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 136539-01-0
ethyl 2-amino-5-chloro-4-thiazole carboxylate

: 135925-33-6
Ethyl 2,5-dichloro-4-thiazolecarboxylate

Guidance literature:: With tert.-butylnitrite; copper dichloride; In acetonitrile; for 1h;

Reference yield:

: 5398-36-7
2-aminothiazole-4-carboxylate

: 135925-33-6
Ethyl 2,5-dichloro-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / acetonitrile / 20 °C

2: isoamylnitrite; CuCl₂ / acetonitrile / 2 h / 0 °C

With N-chloro-succinimide; copper dichloride; isopentyl nitrite; In acetonitrile;
DOI:10.1016/S0040-4039(02)01556-3