N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide

Base Information

• Chemical Name: N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide
• CAS No.: 1240137-87-4
• Molecular Formula: C28H31ClN4O3
• Molecular Weight: 507.02374
• Mol file: 1240137-87-4.mol

Synonyms:N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide;N-((S)-1-Amino-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chlor;N-((2S)-1-amino-3-(4-(8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzamide;N-((S)-1-Amino-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-ch

Chemical Property of N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide

Chemical Property:

• PSA: 101.88000
• LogP: 5.88620
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-((S)-1-Amino-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide

There total 18 articles about N-((S)-1-aMino-3-(4-(8-((S)-1-hydroxyethyl)iMidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-N-{(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide (1240137-67-0) → C28H31ClN4O3 (1240137-87-4)

Guidance literature:

3-chloro-N-{(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide; With hydrazine hydrate; In ethanol; tert-butyl methyl ether; at 40 ℃; for 16h;

With water; In ethanol; tert-butyl methyl ether; at 40 ℃; Further stages;

DOI:10.1021/op100186c

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → C28H31ClN4O3 (1240137-87-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 50 °C

1.2: 50 °C

2.1: water; potassium hydroxide / dimethyl sulfoxide / 80 - 85 °C

2.2: 50 - 60 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Large scale reaction

5.2: 0 °C / Large scale reaction

6.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C

6.2: 40 °C

With N-chloro-succinimide; oxalyl dichloride; water; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane; tert-butyl methyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1021/op100186c

Reference yield:

(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol (66605-57-0) → C28H31ClN4O3 (1240137-87-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

1.2: 2 h / 60 °C

2.1: aluminum (III) chloride / 22 h / -5 °C

2.2: 35 - 50 °C

2.3: 18 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

4.1: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction

5.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C

5.2: 40 °C

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; sodium hydrogencarbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; tert-butyl methyl ether; toluene; acetonitrile; 1.1: Mitsunobu reaction / 2.1: Friedel Crafts acylation;

DOI:10.1021/op100186c

upstream raw materials:

Ethyl 4-hydroxybenzoate

1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate

C₂₆H₃₀N₂O₅

1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate

Downstream raw materials:

3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

3-chloro-N-{(1S)-2-[(N-methylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

3-chloro-N-{(1S)-2-(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)-1-[(3-methyl-2,5-dioxo-1-imidazolidinyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

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