(s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1005342-78-8
Molecular Formula:C19H21FN2O3S
Molecular Weight:376.452
Hs Code.:
Mol file:1005342-78-8.mol

Synonyms:(s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate;(2S)-2-[4-(4-Fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of (s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 8 raw suppliers

Chemical Property of (s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：87.74000
LogP:4.52310

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate

There total 5 articles about (s)-tert-butyl 2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1005342-77-7
tert-butyl (2S)-2-(4-(methoxy(methyl)carbamoyl)-1,3-thiazol-2-yl)pyrrolidine-1-carboxylate

: 352-13-6
4-flourophenylmagnesium bromide

: 1005342-78-8
C₁₉H₂₁FN₂O₃S

Guidance literature:: tert-butyl (2S)-2-(4-(methoxy(methyl)carbamoyl)-1,3-thiazol-2-yl)pyrrolidine-1-carboxylate; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at -55 - -10 ℃;

With water; ammonium chloride; In tetrahydrofuran; at -55 ℃;

Reference yield:

: 251349-54-9,1824349-18-9
(S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)thiazole-4-carboxylic acid

: 1005342-78-8
C₁₉H₂₁FN₂O₃S

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / N,N-dimethyl-formamide / 0.33 h / 21 - 27 °C

1.2: 0.25 h / 17 - 23 °C

1.3: 1 h / 17 - 23 °C

2.1: toluene; tetrahydrofuran / 3 h / -15 - -5 °C / Inert atmosphere

2.2: 4 h / -15 - 28 °C / Inert atmosphere

With dmap; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 117175-41-4,101410-18-8
tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate

: 1005342-78-8
C₁₉H₂₁FN₂O₃S

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.5 h / 23 °C

1.2: 0 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 23 °C

2.2: 0 °C / pH 3

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 4 h / 0 - 23 °C

4.1: tetrahydrofuran / -55 - -10 °C

4.2: -55 °C

With water; potassium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;