Isopropyl imidazolecarbamate

Base Information

• Chemical Name: Isopropyl imidazolecarbamate
• CAS No.: 82998-18-3
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.169
• Mol file: 82998-18-3.mol

Synonyms:Heller-Sarpong reagent;Imidazole-1-carboxylic acid isopropyl ester;IPImC;Isopropyl 1H-imidazole-1-carboxylate;Isopropyl imidazolecarbamate

Chemical Property of Isopropyl imidazolecarbamate

Chemical Property:

• Refractive Index: n20/D1.467
• Flash Point: 108℃
• PSA: 44.12000
• Density: 1.098 g/mL at 25 °C
• LogP: 1.27620
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Isopropyl 1H-imidazole-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isopropyl imidazolecarbamate

There total 2 articles about Isopropyl imidazolecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

isopropyl alcohol (67-63-0,8013-70-5) + 1,1'-carbonyldiimidazole (530-62-1) → isopropyl 1H-imidazole-1-carboxylate (82998-18-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

Reference yield: 71.0%

1H-imidazole (288-32-4) + isopropyl chloroformate (108-23-6) → isopropyl 1H-imidazole-1-carboxylate (82998-18-3)

Guidance literature:

In tetrahydrofuran; toluene; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol1018882

Reference yield: 72.0%

4-[4-((5S)-5-aminomethyl-2-oxo-oxazolidin-3-yl)-2,6-difluoro-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (216869-42-0) + isopropyl 1H-imidazole-1-carboxylate (82998-18-3) → 4-{2,6-difluoro-4-[(5S)-5-(isopropoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (1227688-03-0)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 80 ℃; Inert atmosphere;

upstream raw materials:

isopropyl alcohol

1,1'-carbonyldiimidazole

1H-imidazole

isopropyl chloroformate

Downstream raw materials:

isopropyl N-methylcarbamate

4-{2,6-difluoro-4-[(5S)-5-(isopropoxycarbonylamino-methyl)-2-oxo-oxazolidin-3-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

isopropyl 4-((1r,4r)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)piperidine-1-carboxylate

isopropyl carbazate

Refernces

• 1、 Brunhofer-Bolzer, Gerda,Gabriel, Mario,Studenik, Christian R.,Erker, Thomas. "Discovery of small molecules with vasodilating characteristics and adjustable hydrolytic behavior". . p. 4710 - 4718. Retrieved 2015/08/03.
• 2、 -. "MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO". Page/Page column 120-121. . Retrieved 2013/02/27.