Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid
CAS No.:1160260-94-5
Molecular Formula:C16H19Cl2NO4
Molecular Weight:360.23236
Hs Code.:
Mol file:1160260-94-5.mol

Synonyms:Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid

Chemical Property:

Boiling Point:487.7±45.0 °C(Predicted)
PKA:4.18±0.40(Predicted)
Density:1.347±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid

There total 11 articles about Boc-(+/-)-trans-4-(3,4-dichloro-phenyl)-pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1160262-39-4
tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate

: 1001179-54-9,1160260-94-5
(3S,4R)-1-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 60h;

Reference yield: 64.0%

: 3-methyl 1-tert-butyl (3R*,4S*)-4-(3,4-dichlorophenyl)pyrrolidine-1,3-dicarboxylate

: 1160260-94-5
(3R*,4S*)-1-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; ethanol; for 2h; Heating / reflux;

Reference yield:

: 1001179-51-6
(3S,4R)-1-tert-butyl 3-methyl 4-(3,4-dichlorophenyl)pyrrolidine-1,3-dicarboxylate

: 1001179-54-9,1160260-94-5
(3S,4R)-1-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: (3S,4R)-1-tert-butyl 3-methyl 4-(3,4-dichlorophenyl)pyrrolidine-1,3-dicarboxylate; With methanol; lithium hydroxide; water; at 20 ℃; for 6h;

With hydrogenchloride; In methanol; water;