tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate
• CAS No.: 1160262-39-4
• Molecular Formula: C₂₆H₂₈Cl₂N₂O₅
• Molecular Weight: 519.425
• Mol file: 1160262-39-4.mol

Synonyms:tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) + di-tert-butyl dicarbonate (24424-99-5) + (4R)-4-benzyl-3-{[(3S,4R)-1-benzyl-4-(3,4-dichlorophenyl)pyrrolidin-3-yl]carbonyl}dihydrofuran-2(3H)-one → tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate (1160262-39-4)

Guidance literature:

carbonochloridic acid 1-chloro-ethyl ester; (4R)-4-benzyl-3-{[(3S,4R)-1-benzyl-4-(3,4-dichlorophenyl)pyrrolidin-3-yl]carbonyl}dihydrofuran-2(3H)-one; With triethylamine; In acetonitrile; at 20 - 90 ℃; for 2.5h;

In acetonitrile; at 90 ℃; for 4h;

di-tert-butyl dicarbonate; With triethylamine; In methanol; acetonitrile; at 20 ℃; for 14h;

Reference yield: 81.0%

tert-butyl (3S,4R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-4-(3,4-dichlorophenyl)pyrrolidine-1-carboxylate (1160262-39-4) → (3S,4R)-1-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)pyrrolidine-3-carboxylic acid (1001179-54-9,1160260-94-5)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 60h;

upstream raw materials:

carbonochloridic acid 1-chloro-ethyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

(3S,4R)-1-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)pyrrolidine-3-carboxylic acid