3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate

Base Information

• Chemical Name: 3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate
• CAS No.: 28344-52-7
• Molecular Formula: C22H33FO5S
• Molecular Weight: 428.5578232
• Mol file: 28344-52-7.mol

Synonyms:3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate

Chemical Property of 3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate

Chemical Property:

• Melting Point: 136 - 137 °C (diethyl ether)
• PSA: 78.05000
• LogP: 5.25610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate

There total 4 articles about 3α-Fluoroandrost-5-ene-17β,19-diol 17-acetate 19-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (3R,5S,6R,8S,9S,10R,13S,14S,17S)-3-fluoro-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-17-yl ester (28344-39-0) → 3α-Fluor-17β-acetoxy-19-mesyl-5-androsten (28344-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. HBr, benzene, (ii) Pb(OAc)4, CaCO₃, cyclohexane, (iii) Zn, aq. AcOH

Reference yield:

3α-Fluor-17β-acetoxy-19-hydroxy-5-androsten (28344-47-0) + methanesulfonyl chloride (124-63-0) → 3α-Fluor-17β-acetoxy-19-mesyl-5-androsten (28344-52-7)

Guidance literature:

Reference yield:

→ Acetic acid 3-fluoro-10-methanesulfonyloxymethyl-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (28344-52-7,28344-71-0)

Guidance literature:

entspr. 19-Alkohol, Mesylchlorid;

upstream raw materials:

3α-Fluor-17β-acetoxy-19-hydroxy-5-androsten

methanesulfonyl chloride

Acetic acid (3R,5S,6R,8S,9S,10R,13S,14S,17S)-3-fluoro-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-17-yl ester