2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one

Base Information

Chemical Name:2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one
CAS No.:13212-61-8
Molecular Formula:C₁₀H₁₁NO₃
Molecular Weight:193.202
Hs Code.:
Mol file:13212-61-8.mol

Synonyms:2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one;2-Ethyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one

Suppliers and Price of 2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one

Chemical Property:

Melting Point:128 - 130 °C (ethanol)
PSA：49.77000
LogP:1.64480

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one

There total 3 articles about 2-Ethyl-4-hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 13212-58-3
2-(2-nitro-phenoxy)-butyric acid ethyl ester

: 13212-61-8
2-ethyl-4-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: With ammonium chloride; zinc; In ethanol; for 2h;
DOI:10.1016/S0014-827X(00)00098-7

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 13212-61-8
2-ethyl-4-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: MeOK / methanol

1.2: 0.5 h / Heating

2.1: 41 percent / aq. NH₄Cl; Zn / ethanol / 2 h

With potassium methanolate; ammonium chloride; zinc; In methanol; ethanol;
DOI:10.1016/S0014-827X(00)00098-7

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 13212-61-8
2-ethyl-4-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 1 h

2: palladium 10% on activated carbon; sodium tetrahydroborate / water; 1,4-dioxane

With sodium tetrahydroborate; palladium 10% on activated carbon; potassium hydroxide; In 1,4-dioxane; ethanol; water;
DOI:10.1080/00397911.2018.1554146