bortezoMib iMpurity H

Base Information

• Chemical Name: bortezoMib iMpurity H
• CAS No.: 1446194-56-4
• Molecular Formula: C₁₉H₂₄N₄O₂
• Molecular Weight: 340.425
• Mol file: 1446194-56-4.mol

Synonyms:bortezoMib iMpurity H;(S)-N-(1-(isopentylaMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide;Bortezomib Imp.H;Bortezomib Impurity 11

Chemical Property of bortezoMib iMpurity H

Chemical Property:

• PSA: 83.98000
• LogP: 2.76180

Purity/Quality:

≥95% ^*data from raw suppliers

N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide is an impurity of Bortezomib (B675700) which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

Technology Process of bortezoMib iMpurity H

There total 1 articles about bortezoMib iMpurity H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-amino-3-methylbutane (107-85-7) + (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid (114457-94-2,1608986-16-8) → (S)-N-(1-(isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide (1446194-56-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jacs.9b12013

upstream raw materials:

1-amino-3-methylbutane

(S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid