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107-85-7 Usage


ISOAMYLAMINE, also known as Isopentylamine, is a primary aliphatic amine with the chemical formula butan-1-amine carrying a methyl substituent at position 3. It is characterized by its unpleasant, ammoniacal odor and is a colorless, flammable liquid. ISOAMYLAMINE is miscible with water, alcohol, chloroform, and ether, and is commonly found in various botanical sources, as well as in the degradation products of proteins.


Used in Organic Syntheses:
ISOAMYLAMINE is used as a reagent in organic syntheses for various chemical reactions due to its amine functional group, which can participate in a wide range of reactions, such as alkylation, acylation, and reductive amination.
Used in the Food Industry:
ISOAMYLAMINE is used as a flavoring agent and additive in the food industry, contributing to the taste and aroma of various products, including apple, banana, grapes, kale, rutabaga, tomato, wheat bread, cheeses, caviar, cooked beef and pork.
Used in the Beverage Industry:
ISOAMYLAMINE is used as a flavor enhancer in the production of hop oil, sherry, beer, red and white wine, cocoa, and coffee, where it helps to improve the overall taste and aroma of these beverages.
Used in the Pharmaceutical Industry:
ISOAMYLAMINE can be utilized in the synthesis of various pharmaceutical compounds due to its reactive amine group, which can be involved in the formation of amide bonds, crucial for the development of drugs with specific therapeutic properties.


From isoamyl chloride and sodamide in liquid ammonia; by reduction of isoamyl nitrile.

Flammability and Explosibility


Check Digit Verification of cas no

The CAS Registry Mumber 107-85-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 107-85:
47 % 10 = 7
So 107-85-7 is a valid CAS Registry Number.

107-85-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • Alfa Aesar

  • (L02260)  Isopentylamine, 99%   

  • 107-85-7

  • 25g

  • 359.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name isopentylamine

1.2 Other means of identification

Product number -
Other names Isopentylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107-85-7 SDS

107-85-7Relevant articles and documents

High-Precision Position-Specific Isotope Analysis of 13C/ 12C in Leucine and Methionine Analogues

Sacks, Gavin L.,Brenna, J. Thomas

, p. 5495 - 5503 (2003)

We report an automated method for high-precision position-specific isotope analysis (PSIA) of carbon in amino acid analogues. Carbon isotope ratios are measured for gas-phase pyrolysis fragments from multiple sources of 3-methylthiopropylamine (3MTP) and isoamylamine (IAA), the decarboxylated analogues of methionine and leucine, using a home-built gas chromatography (GC)-pyrolysis-GC preparation system coupled to a combustion-isotope ratio mass spectrometry system. Over a temperature range of 620-900 °C, the characteristic pyrolysis products for 3MTP were CH4, C 2H6, HCN, and CH3CN and for IAA products were propylene, isobutylene, HCN, and CH3CN. Fragment origin was confirmed by 13C-labeling, and fragments used for isotope analysis were generated from unique moieties with >95% structural fidelity. Isotope ratios for the fragments were determined with an average precision of SD(δ13C) 13C) 13C values of fragments were invariant over a range of pyrolysis temperatures. The Δδ13C of complementary fragments in IAA was within 0.8‰ of the Δδ13C of the parent compounds, indicating that pyrolysis-induced isotopic fractionation is effectively taken into account with this calibration procedure. Using Δδ 13C values of fragments, Δδ13C values were determined for all four carbon positions of 3MTP and for C1, C2, and the propyl moiety of IAA, either directly or indirectly by mass balance. Large variations in position-specific isotope ratios were observed in samples from different commercial sources. Most dramatically, two 3MTP sources differed by 16.30‰ at C1, 48.33‰ at C2, 0.37‰ at C3, and 5.36‰ at C(methyl). These PSIA techniques are suitable for studying subtle changes in intramolecular isotope ratios due to natural processes.

New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti

Gulzar, Tahsin,Uddin, Nizam,Siddiqui, Bina Shaheen,Naqvi, Syed N.H.,Begum, Sabira,Tariq, Rajput Muhammed

, p. 219 - 223 (2013)

Six bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EI-MS, FAB-MS, 1H and 13C NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (1H-1H COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method.

Design, synthesis and the structure-activity relationship of agonists targeting on the ALDH2 catalytic tunnel

Cheng, Ming-Che,Lo, Wei-Chi,Chang, Yu-Wen,Lee, Shoei-Sheng,Chang, Chia-Chuan

, (2020/09/15)

ALDH2, a key enzyme in the alcohol metabolism process, detoxifies several kinds of toxic small molecular aldehydes, which induce severe organ damages. The development of novel Alda-1 type ALDH2 activators was mostly relied on HTS but not rational design so far. To clarify the structure–activity relationship (SAR) of the skeleton of Alda-1 analogs by synthesis of the least number of analogs, we prepared 31 Alda-1 analogs and 3 isoflavone derivatives and evaluated for their ALDH2-activating activity. Among these, the ALDH2-activating activity of mono-halogen-substituted (Cl and Br) N-piperonylbenzamides 3b and 3 k, and non-aromatic amides 8a-8c, were 1.5–2.1 folds higher than that of Alda-1 at 20 μM. The relationship between binding affinity in computer aided molecular docking model and the ALDH2-activating activity assays were clarified as follows: for Alda-1 analogs, with the formation of halogen bonds, the enzyme-activating activity was found to follow a specific regression curve within the range between ?5 kcal/mol and ?4 kcal/mol. For isoflavone derivatives, the basic moiety on the B ring enhance the activating activity. These results provide a new direction of utilizing computer-aided modeling to design novel ALDH2 agonists in the future.

Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds


Paragraph 0027-0030; 0051-0055, (2020/05/30)

The invention discloses a method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds. The method comprises the following steps: 1) mixing nickel nitrate hexahydrate, citric acid and an organic solvent, carrying out heating and stirring until a colloidal material is obtained, drying the colloidal material, roasting the colloidal material in a protective atmosphere, pickling, washing and drying a roasted product, and performing a partial oxidation reaction on a dried product in an oxygen-nitrogen mixed atmosphere to obtain a catalyst for a reductive amination reaction; and 2) mixing aldehyde or ketone compounds, a methanol solution of ammonia and the reductive amination reaction catalyst, introducing hydrogen, and carrying out a reductive amination reaction. The method has the advantages of high primary amine yield, high selectivity, wide aldehyde ketone substrate range, short reaction time, mild reaction conditions, low cost, greenness, economicalperformance and the like; the used reductive amination reaction catalyst can be recycled more than 10 times, and the catalytic activity of the catalyst is not obviously changed in gram-level reactions; and the method is suitable for large-scale application.

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

Jagadeesh, Rajenahally V.,Murugesan, Kathiravan,Alshammari, Ahmad S.,Neumann, Helfried,Pohl, Marga-Martina,Radnik, J?rg,Beller, Matthias

, p. 326 - 332 (2017/09/28)

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

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