2-BROMO-3-METHYLBUTYRIC ACID

Base Information

• Chemical Name: 2-BROMO-3-METHYLBUTYRIC ACID
• CAS No.: 10323-40-7
• Molecular Formula: C₅H₉BrO₂
• Molecular Weight: 181.029
• Mol file: 10323-40-7.mol

Synonyms:2-Bromo-3-methylbutyric acid;Butanoic acid, 2-bromo-3-methyl-, (±)-;2-Bromo-3-methylbutanoic acid;

Chemical Property of 2-BROMO-3-METHYLBUTYRIC ACID

Chemical Property:

• Melting Point: 44°C
• Refractive Index: 1.4930 (estimate)
• PSA: 37.30000
• Density: 1.4590
• LogP: 1.49050

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-3-METHYLBUTYRIC ACID

There total 33 articles about 2-BROMO-3-METHYLBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methylbutyric acid (503-74-2) → 2-bromoisovaleric acid (10323-40-7,565-74-2)

Guidance literature:

With bromine; phosphorus trichloride; for 4.5h; Heating;

DOI:10.1039/b618540a

Reference yield: 81.0%

D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → 2-bromoisovaleric acid (10323-40-7,565-74-2)

Guidance literature:

With pyridinium polyhydrogen fluoride; potassium bromide; sodium nitrite; for 48h; Ambient temperature;

DOI:10.1002/hlca.19830660404

Reference yield: 73.0%

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) → (R)-2-bromoisovaleric acid (76792-22-8,10323-40-7,26782-75-2,565-74-2)

Guidance literature:

With sulfuric acid; potassium bromide; sodium nitrite; at 0 - 20 ℃;

upstream raw materials:

3-methylbutyric acid

2-bromo-3-methyl-butyraldehyde

dibromoacetonitrile

isobutyraldehyde

Downstream raw materials:

ethyl 2-bromoisovalerate

2-methoxy-3-methylbutanoic acid

3-Methylbutenoic acid

2-hydroxy-3-methylbutanoic acid

Refernces

• 1、 Wu, Peng,Zhang, Mengjie,Zhang, Yinjun,Wang, Zhao,Zheng, Jianyong. "A novel lipase from Aspergillus oryzae catalyzed resolution of (R,S)-ethyl 2-bromoisovalerate". . p. 231 - 238. Retrieved 2020.
• 2、 Smissman. "-". . p. 5805. Retrieved 1954.
• 3、 Coric, Pascale,Turcaud, Serge,Meudal, Hervé,Roques, Bernard Pierre,Fournie-Zaluski, Marie-Claude. "Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors". . p. 1210 - 1219. Retrieved 1996.