BAY-1217389

Base Information

Chemical Name:BAY-1217389
CAS No.:1554458-53-5
Molecular Formula:C27H24F5N5O3
Molecular Weight:561.5
Hs Code.:
Mol file:1554458-53-5.mol

Synonyms:BAY-1217389

Suppliers and Price of BAY-1217389

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
10mg
$ 440.00

DC Chemicals
BAY1217389 >98%
500 mg
$ 1500.00

ChemScene
BAY1217389 99.94%
25mg
$ 340.00

ChemScene
BAY1217389 99.94%
2mg
$ 60.00

ChemScene
BAY1217389 99.94%
50mg
$ 610.00

Cayman Chemical
BAY 12-17389 ≥98%
5mg
$ 116.00

Cayman Chemical
BAY 12-17389 ≥98%
25mg
$ 363.00

Cayman Chemical
BAY 12-17389 ≥98%
1mg
$ 29.00

Cayman Chemical
BAY 12-17389 ≥98%
10mg
$ 218.00

AK Scientific
CID78320750
1mg
$ 133.00

Total 13 raw suppliers

Chemical Property of BAY-1217389

Chemical Property:

PSA：89.78000
LogP:6.50420

Purity/Quality:

99%, ^*data from raw suppliers

N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide inhibits monopolar spindle 1, which is a serine/threonine/tyrosine kinase involved in cell division. It is also a potential antitumor agent.

Technology Process of BAY-1217389

There total 11 articles about BAY-1217389 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 261763-29-5
2,3-difluoro-4-methoxy-phenol

: 1365243-95-3
4-{6-bromo-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropyl-2-methylbenzamide

: 1554458-53-5
N-cyclopropyl-4-{6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: 2,3-difluoro-4-methoxy-phenol; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

4-{6-bromo-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropyl-2-methylbenzamide; In dimethyl sulfoxide; mineral oil; at 130 ℃;

Reference yield:

: 1206487-36-6
6,8-dibromoimidazo[1,2-b]pyridazine

: 1554458-53-5
N-cyclopropyl-4-{6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: tetrahydrofuran / 50 - 80 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran; water / 12 h / 45 °C / Inert atmosphere

4.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

4.2: 130 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium hydride; caesium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 345965-99-3
4-bromo-N-cyclopropyl-2-methylbenzamide

: 1554458-53-5
N-cyclopropyl-4-{6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: XPhos; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran; water / 12 h / 45 °C / Inert atmosphere

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

3.2: 130 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; sodium hydride; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; mineral oil;