8-Bromo-6-chloroimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
• CAS No.: 933190-51-3
• Molecular Formula: C6H3BrClN3
• Molecular Weight: 232.467
• Hs Code.: 2933990090
• Mol file: 933190-51-3.mol

Synonyms:Imidazo[1,2-b]pyridazine, 8-bromo-6-chloro-;

Chemical Property of 8-Bromo-6-chloroimidazo[1,2-b]pyridazine

Chemical Property:

• Refractive Index: 1.767
• PKA: 0.73±0.30(Predicted)
• PSA: 30.19000
• Density: 2.03 g/cm³
• LogP: 2.14520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-6-chloroimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Bromo-6-chloroimidazo[1,2-b]pyridazine

There total 4 articles about 8-Bromo-6-chloroimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloroethanal (107-20-0) + 4-bromo-6-chloro-3-pyridazineamine (446273-59-2) → 8-bromo-6-chloro-imidazo[1,2-b]pyridazine (933190-51-3)

Guidance literature:

In ethanol; at 50 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01721

Reference yield: 98.0%

4-bromo-6-chloro-3-pyridazineamine (446273-59-2) + chloroacetaldehyde diethyl acetal (621-62-5) → 8-bromo-6-chloro-imidazo[1,2-b]pyridazine (933190-51-3)

Guidance literature:

With toluene-4-sulfonic acid; In isopropyl alcohol; at 80 ℃; for 20h;

DOI:10.1021/jm301367c

Reference yield:

2-chloroethanal (107-20-0) + 4-bromo-6-chloro-3-pyridazineamine (446273-59-2) → 8-bromo-6-chloro-imidazo[1,2-b]pyridazine (933190-51-3) + 6,8-dichloro-imidazo[1,2-b]pyridazine (1161847-29-5)

Guidance literature:

2-chloroethanal; 4-bromo-6-chloro-3-pyridazineamine; In ethanol; water; for 2h; Reflux;

With sodium carbonate; In ethanol; water; ethyl acetate;

upstream raw materials:

2-chloroethanal

4-bromo-6-chloro-3-pyridazineamine

chloroacetaldehyde diethyl acetal

Downstream raw materials:

6-chloro-N-(4-ethoxy-phenyl)-imidazo[1,2-b]pyridazin-8-amine

3-(2-methoxyphenyl)-8-(4-methylpyridin-3-yl)imidazo[1,2-b]pyridazine

4-(3-(2-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-8-yl)isoquinoline

3-(2,4-dichlorophenyl)-8-(4-methylpyridin-3-yl)imidazo[1,2-b]pyridazine