1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE

Base Information

• Chemical Name: 1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE
• CAS No.: 1162336-72-2
• Molecular Formula: C8H18N4O3
• Molecular Weight: 246.31
• Hs Code.: 2924190090
• Mol file: 1162336-72-2.mol

Synonyms:11-AZIDO-3,6,9-TRIOXAUNDECAN-1-AMINE;1-Azido-3,6,9-trioxaundecane-11-amine;2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethanamine;2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylamine;1-Azido-4,7,10-trioxa-13-tridecanamine≥ 98% (TLC);N3-TOTA

Chemical Property of 1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE

Chemical Property:

• Refractive Index: n20/D 1.470
• Boiling Point: 198-202
• PSA: 103.46000
• Density: 1.10 g/mL at 20 °C(lit.)
• LogP: 1.23846

Purity/Quality:

98%Min ^*data from raw suppliers

11-Azido-3,6,9-trioxaundecan-1-amine technical, ≥90% (GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE

There total 4 articles about 1-AMINO-11-AZIDO-3,6,9-TRIOXAUNDECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)carbamate (1162070-33-8) → 3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine (1162336-72-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1039/c3cc47003b DOI:10.1002/chem.201403965

Reference yield:

4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) → 3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine (1162336-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 12 h / 20 °C

2: imidazole-1-sulfonyl azide hydrochloride; potassium carbonate; copper(ll) sulfate pentahydrate / methanol / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1039/c3cc47003b

Reference yield:

tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate (320635-20-9) → 3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine (1162336-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; potassium carbonate / methanol / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1002/chem.201403965

upstream raw materials:

4,7,10-trioxa-1,13-diaminotridecane

tert-butyl (3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)carbamate

tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate

Downstream raw materials:

N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide

N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-tosyl-2-(tosylmethyl)propanoyl)benzamide

Refernces

• 1、 Wang, Tao,Ng, David Y. W.,Wu, Yuzhou,Thomas, Jessica,Tamtran, Thuy,Weil, Tanja. "Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release". . p. 1116 - 1118. Retrieved 2014/01/17.