N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide

Base Information

• Chemical Name: N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide
• CAS No.: 1528459-43-9
• Molecular Formula: C₃₅H₄₄N₄O₅S₂
• Molecular Weight: 664.89
• Mol file: 1528459-43-9.mol

Synonyms:N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide

Chemical Property of N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide

There total 7 articles about N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine (1162336-72-2) + 4-(3-(p-tolylthio)-2-((p-tolylthio)methyl)propanoyl)benzoic acid (124242-93-9) → N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide (1528459-43-9)

Guidance literature:

4-[2,2-bis[(p-tolylsulfanyl)methyl]acetyl]benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc47003b

Reference yield:

4,7,10-trioxa-1,13-diaminotridecane (4246-51-9) → N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide (1528459-43-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane / 12 h / 20 °C

2.1: imidazole-1-sulfonyl azide hydrochloride; potassium carbonate; copper(ll) sulfate pentahydrate / methanol / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3cc47003b

Reference yield:

tert-butyl (3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)carbamate (1162070-33-8) → N-(3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)-4-(3-(p-tolylthio)-2-((p-tolylthio) methyl)propanoyl)benzamide (1528459-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3cc47003b

upstream raw materials:

4,7,10-trioxa-1,13-diaminotridecane

tert-butyl (3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propyl)carbamate

3-(2-(2-(3-azidopropoxy)ethoxy)ethoxy)propan-1-amine

4-(3-(p-tolylthio)-2-((p-tolylthio)methyl)propanoyl)benzoic acid