N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE

Base Information

• Chemical Name: N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE
• CAS No.: 64415-10-7
• Molecular Formula: C7H11Cl3N2
• Molecular Weight: 229.53
• Mol file: 64415-10-7.mol

Synonyms:N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE;[(2-chlorophenyl)methyl]hydrazine dihydrochloride

Chemical Property of N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE

Chemical Property:

• PSA: 38.05000
• LogP: 3.19650

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Chlorobenzyl)hydrazineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE

There total 2 articles about N-(O-CHLOROBENZYL)HYDRAZIDE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-((2-chlorobenzyl)amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + [(2-chlorophenyl)methyl]hydrazine dihydrochloride (64415-10-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield: 63.0%

1-chloro-2-(chloromethyl)benzene (611-19-8) → [(2-chlorophenyl)methyl]hydrazine dihydrochloride (64415-10-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 ℃; for 2h;

Reference yield:

[(2-chlorophenyl)methyl]hydrazine dihydrochloride (64415-10-7) → methyl 2-((1-[(o-chlorophenyl)methyl]-5-(m-methoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-ethylbutanoate

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 3 h / 65 °C

2.1: lithium borohydride / tetrahydrofuran / 16.08 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 4.08 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 16 h / 20 °C

With lithium borohydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1-chloro-2-(chloromethyl)benzene

Refernces

• 1、 -. "HETEROCYCLIC INHIBITORS OF MCT4". Paragraph 0560. . Retrieved 2018/06/30.