1,2-Butanediamine,N1,N1,3-trimethyl-(9CI)

Base Information

• Chemical Name: 1,2-Butanediamine,N1,N1,3-trimethyl-(9CI)
• CAS No.: 773045-76-4
• Molecular Formula: C₇H₁₈N₂
• Molecular Weight: 130.233
• Hs Code.: 2921290090
• Mol file: 773045-76-4.mol

Synonyms:1,2-Butanediamine,N1,N1,3-trimethyl-(9CI);N1,N1,3-TriMethyl-1,2-butanediaMine 2HCl

Chemical Property of 1,2-Butanediamine,N1,N1,3-trimethyl-(9CI)

Chemical Property:

• PSA: 29.26000
• LogP: 1.23160

Purity/Quality:

99%min ^*data from raw suppliers

N1,N1,3-Trimethyl-1,2-butanediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Butanediamine,N1,N1,3-trimethyl-(9CI)

There total 7 articles about 1,2-Butanediamine,N1,N1,3-trimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-L-valinamide hydrochloride (154462-98-3) → (S)-N1,N1,3-trimethylbutane-1,2-diamine (847696-16-6,486414-51-1,773045-76-4)

Guidance literature:

N,N-dimethyl-L-valinamide hydrochloride; With lithium aluminium tetrahydride; In tetrahydrofuran; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; ipa; for 2h;

Reference yield:

(S)-tert-butyl (1-(dimethylamino)-3-methyl-1-oxobutan-2-yl)carbamate (132393-07-8) → (S)-N1,N1,3-trimethylbutane-1,2-diamine (847696-16-6,486414-51-1,773045-76-4)

Guidance literature:

(S)-tert-butyl (1-(dimethylamino)-3-methyl-1-oxobutan-2-yl)carbamate; With acetyl chloride; In methanol; at 0 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1021/ol702074a

Reference yield:

(2R)-2-amino-N,N,3-trimethylbutanamide (230643-53-5) → (R)-3,N1,N1-trimethyl-butane-1,2-diamine (486414-51-1,773045-76-4)

Guidance literature:

(2R)-2-amino-N,N,3-trimethylbutanamide; With lithium aluminium tetrahydride; In tetrahydrofuran; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; ipa; for 2h;

upstream raw materials:

(2R)-2-amino-N,N,3-trimethylbutanamide

(S)-tert-butyl (1-(dimethylamino)-3-methyl-1-oxobutan-2-yl)carbamate

N,N-dimethyl-L-valinamide hydrochloride

t-Boc-L-valine

Downstream raw materials:

1-((1R,2R)-2-aminocyclohexyl)-3-((S)-1-(dimethylamino)-3-methylbutan-2-yl)thiourea

Refernces

• 1、 Tan, Jian-Ping,Yu, Peiyuan,Wu, Jia-Hong,Chen, Yuan,Pan, Jianke,Jiang, Chunhui,Ren, Xiaoyu,Zhang, Hong-Su,Wang, Tianli. "Bifunctional Phosphonium Salt Directed Enantioselective Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone Methides with α-Halogenated Ketones". . p. 7298 - 7302. Retrieved 2019/10/02.
• 2、 Kuranaga, Takefumi,Sesoko, Yusuke,Sakata, Komei,Maeda, Naoya,Hayata, Atsushi,Inoue, Masayuki. "Total synthesis and complete structural assignment of Yaku'amide A". . p. 5467 - 5474. Retrieved 2013/05/22.