3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

Base Information

• Chemical Name: 3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
• CAS No.: 910543-72-5
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.038
• Hs Code.: 2933399090
• Mol file: 910543-72-5.mol

Synonyms:3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-Amino-5-bromo-1-methylp...;l-Methyl-3-aMino-5-broMo-l-H-pyridin-2-one;3-amino-5-bromo-1-methyl-1,2-dihydropyridin-2-one;3-amino-5-bromo-1-methyl-2(1H)-Pyridinone

Chemical Property of 3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

Chemical Property:

• Boiling Point: 258.7±40.0 °C(Predicted)
• PKA: 2?+-.0.20(Predicted)
• PSA: 48.02000
• Density: 1.713±0.06 g/cm3(Predicted)
• LogP: 1.31120
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

3-Amino-5-bromo-1-methylpyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Amino-5-bromo-1-methylpyridin-2(1H)-one is a useful reagent used in the preparation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton''s tyrosine kinase inhibitors with antiarthritic activity for the treatment of Rheumatoid arthritis.

Technology Process of 3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

There total 8 articles about 3-AMINO-5-BROMO-1-METHYLPYRIDIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromo-1-methyl-3-nitropyridine-2(1H)-one (153888-45-0) → 3-amino-5-bromo-1-methyl-2H-pyridin-2-one (910543-72-5)

Guidance literature:

With hydrogenchloride; iron; acetic acid; sodium hydroxide; In dichloromethane; water; at 35 ℃; for 2h; Large scale;

DOI:10.1021/op4001077

Reference yield: 83.8%

(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid tert-butyl ester → 3-amino-5-bromo-1-methyl-2H-pyridin-2-one (910543-72-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 70.6%

5-bromo-3-[(diphenylmethylidene)amino]-1-methyl-1,2-dihydropyridin-2-one → 3-amino-5-bromo-1-methyl-2H-pyridin-2-one (910543-72-5)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1021/acsmedchemlett.0c00249

upstream raw materials:

3,5-dibromo-1-methyl-1H-pyridin-2-one

5-bromo-1-methyl-3-nitropyridine-2(1H)-one

Benzophenone imine

5-bromo-3-nitro-1H-pyridin-2-one

Downstream raw materials:

N-[3-(5-amino-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-2-methyl-phenyl]-4-tert-butyl-benzamide

6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

C₃₄H₃₄N₆O₅

6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

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