5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE

Base Information

• Chemical Name: 5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE
• CAS No.: 153888-45-0
• Molecular Formula: C₆H₅BrN₂O₃
• Molecular Weight: 233.021
• Hs Code.: 2933399090
• Mol file: 153888-45-0.mol

Synonyms:5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE;5-BroMo-1-Methyl-3-nitrop...;5-BroMo-1-Methyl-3-nitro-1H-pyridin-2-one;5-bromo-1-methyl-3-nitro-1,2-dihydropyridin-2-one

Chemical Property of 5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE

Chemical Property:

• PSA: 67.82000
• LogP: 1.57920

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-1-methyl-3-nitropyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Bromo-1-methyl-3-nitropyridin-2(1H)-one is an intermediate used in the synthesis of functionalized pyridone derivatives.

Technology Process of 5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE

There total 6 articles about 5-BROMO-1-METHYL-3-NITROPYRIDIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-bromo-3-nitro-1H-pyridin-2-one (15862-34-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + methyl iodide (74-88-4) → 5-bromo-1-methyl-3-nitropyridine-2(1H)-one (153888-45-0)

Guidance literature:

5-bromo-3-nitro-1H-pyridin-2-one; N,N-dimethyl-formamide; With potassium carbonate; at 20 ℃; for 0.25h; Reflux;

methyl iodide; at 20 ℃; for 16h;

Reference yield: 85.0%

5-bromo-3-nitro-2-pyridone (15862-34-7) + methyl iodide (74-88-4) → 5-bromo-1-methyl-3-nitropyridine-2(1H)-one (153888-45-0)

Guidance literature:

5-bromo-3-nitro-2-pyridone; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 76.0%

5-bromo-3-nitro-1H-pyridin-2-one (15862-34-7) + dimethyl sulfate (77-78-1) → 5-bromo-1-methyl-3-nitropyridine-2(1H)-one (153888-45-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at -5 - 25 ℃; for 13.5h; Large scale;

DOI:10.1021/op4001077

upstream raw materials:

5-bromo-3-nitro-2-pyridone

methyl iodide

5-bromo-3-nitro-1H-pyridin-2-one

N,N-dimethyl-formamide

Downstream raw materials:

6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

C₃₄H₃₄N₆O₅

6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

5-tert-butyl-2-(2-(hydroxymethyl)-3-(1-methyl-5-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoindolin-1-one