2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE

Base Information

• Chemical Name: 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE
• CAS No.: 35095-93-3
• Molecular Formula: C26H24ClN5O5
• Molecular Weight: 521.96
• Mol file: 35095-93-3.mol

Synonyms:2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE;2-Amino-6-chloro-9-(2'-deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)purine;2-AMino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-(O-p-toluoyl))riboside;2-AMino-6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)purine;6-Chloro-9-[2-deoxy-3,5-bis-O-(4-methylbenzoyl)-beta-D-erythro-pentofuranosyl]-9H-purin-2-amine

Chemical Property of 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE

Chemical Property:

• PSA: 131.45000
• LogP: 4.63000

Purity/Quality:

97% ^*data from raw suppliers

(2R,3S,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl4-methylbenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE

There total 2 articles about 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-chloro-2-deoxy-3,5-di-O-para-toluoyl-α-D-ribofuranose + water (7732-18-5) + 2-Amino-6-chloropurin (10310-21-1) → 2-Amino-6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine (35095-93-3)

Guidance literature:

In dichloromethane; acetonitrile;

Reference yield: 51.0%

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 2-Amino-6-chloropurin (10310-21-1) → 2-Amino-6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine (35095-93-3) + 2-Amino-6-chloro-7-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine (120595-71-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) acetonitrile, RT, 30 min; 2) acetonitrile, 20 h;

DOI:10.1002/jhet.5570250653

Reference yield: 68.0%

2-Amino-6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine (35095-93-3) → 2-Amino-6-chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine (120595-72-4,141771-78-0)

Guidance literature:

With ammonia; In methanol; for 20h; Ambient temperature;

DOI:10.1002/jhet.5570250653

upstream raw materials:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

2-Amino-6-chloropurin

water

Downstream raw materials:

2-amino-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-6-methoxyaminopurine

6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-2-p-toluamidopurine

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine

2-Amino-6-chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine