4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

Chemical Name:4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.:683274-46-6
Molecular Formula:C17H25N3O4
Molecular Weight:335.403
Hs Code.:2933599090
Mol file:683274-46-6.mol

Synonyms:BUTTPARK 47\08-04;4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(2-AMINO-4-METHOXYCARBONYLPHENYL)PIPERAZINE-1-CARBOXYLATE

Suppliers and Price of 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

PSA：85.10000
LogP:2.69660

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 3 articles about 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: tert-butyl 4-[4-(methoxycarbonyl)-2-nitrophenyl]piperazine-1-carboxylate

: 683274-46-6
tert-butyl 4-[2-amino-4-(methoxycarbonyl)phenyl]piperazine-1-carboxylate

Guidance literature:: tert-butyl 4-[4-(methoxycarbonyl)-2-nitrophenyl]piperazine-1-carboxylate; With acetic acid; iron; In 1,4-dioxane; water; at 20 ℃; Cooling with ice;

With sodium hydrogencarbonate; In 1,4-dioxane; water;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 683274-46-6
tert-butyl 4-[2-amino-4-(methoxycarbonyl)phenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Reflux

2: hydrogen; nickel / methanol / 8 h / 20 °C

With hydrogen; nickel; N-ethyl-N,N-diisopropylamine; In methanol; ethanol;

Reference yield:

: 14719-83-6
methyl 3-nitro-4-chlorobenzoate

: 683274-46-6
tert-butyl 4-[2-amino-4-(methoxycarbonyl)phenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Reflux

2: hydrogen; nickel / methanol / 8 h / 20 °C

With hydrogen; nickel; N-ethyl-N,N-diisopropylamine; In methanol; ethanol;