METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE

Base Information

• Chemical Name: METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE
• CAS No.: 1203685-30-6
• Molecular Formula: C₁₂H₁₅NO₂*ClH
• Molecular Weight: 241.718
• Hs Code.: 2933990090
• Mol file: 1203685-30-6.mol

Synonyms:METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE;4-Pyrrolidin-2-yl-benzoic acid methyl ester hydrochloride;4-(2-pyrrolidinyl)Benzoic acid methyl ester hydrochloride

Chemical Property of METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE

Chemical Property:

• PSA: 38.33000
• LogP: 3.02850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-(Pyrrolidin-2-yl)benzoateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE

There total 3 articles about METHYL 4-(PYRROLIDIN-2-YL)BENZOATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1243198-96-0) → C12H15NO2*ClH (1203685-30-6,1381927-79-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 25h;

DOI:10.1016/j.bmcl.2013.12.090

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → C12H15NO2*ClH (1203685-30-6,1381927-79-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Reflux

2: hydrogen; 5%-palladium/activated carbon / acetic acid / 24 h / 25 °C / 1551.49 Torr

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 25 h / 25 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.12.090

Reference yield:

tert-butyl 2-(4-(methoxycarbonyl)phenyl)-1H-pyrrole-1-carboxylate (1329059-04-2) → C12H15NO2*ClH (1203685-30-6,1381927-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / acetic acid / 24 h / 25 °C / 1551.49 Torr

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 25 h / 25 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In 1,4-dioxane; dichloromethane; acetic acid;

DOI:10.1016/j.bmcl.2013.12.090

upstream raw materials:

2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

4-methoxycarbonylphenyl bromide

tert-butyl 2-(4-(methoxycarbonyl)phenyl)-1H-pyrrole-1-carboxylate

Downstream raw materials:

C₂₈H₂₇F₃N₂O₃

C₂₇H₂₅F₃N₂O₃

C₂₅H₂₂F₃NO₂