2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1243198-96-0
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 1243198-96-0.mol

Synonyms:2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

There total 18 articles about 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 4-iodobenzoate (619-44-3) + N-tert-butoxycarbonyl-proline (15761-39-4,59433-50-0) → 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1243198-96-0)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); titanium(IV) oxide; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; for 18h; Inert atmosphere; Irradiation;

DOI:10.1021/acscatal.6b03687

Reference yield: 92.2%

4-methoxycarbonylphenyl bromide (619-42-1) + N-tert-butoxycarbonyl-proline (15761-39-4,59433-50-0) → 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1243198-96-0)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; Inert atmosphere; Irradiation;

DOI:10.1002/ejoc.202101180

Reference yield: 90.0%

→ 2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1243198-96-0)

Guidance literature:

With [nickel(II)dichloride(dimethoxyethane)]; Ir[dF(CF₃)ppy]2(dtbbpy)PF₆; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; for 72h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

4-methoxycarbonylphenyl bromide

tert-butyl pyrrolidine-1-carboxylate

N-boc-2-pyrroleboronic acid

tert-butyl 2-(4-(methoxycarbonyl)phenyl)-1H-pyrrole-1-carboxylate

Downstream raw materials:

C₁₂H₁₅NO₂*ClH

C₂₅H₂₂F₃NO₂

C₂₈H₂₇F₃N₂O₃

C₂₇H₂₅F₃N₂O₃