4-bromo-3-(hydroxymethyl)phenol

Base Information

• Chemical Name: 4-bromo-3-(hydroxymethyl)phenol
• CAS No.: 2737-20-4
• Molecular Formula: C7H7BrO2
• Molecular Weight: 203.035
• Hs Code.: 9999999999
• Mol file: 2737-20-4.mol

Synonyms:4-bromo-3-(hydroxymethyl)phenol;2-bromo-5-hydroxy-benzyl alcohol

Chemical Property of 4-bromo-3-(hydroxymethyl)phenol

Chemical Property:

• Melting Point: 142 °C
• Boiling Point: 341.2±27.0 °C(Predicted)
• PKA: 9.17±0.18(Predicted)
• PSA: 40.46000
• Density: 1.722±0.06 g/cm3(Predicted)
• LogP: 1.64700

Purity/Quality:

98%, ^*data from raw suppliers

4-Bromo-3-hydroxymethyl-phenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-3-(hydroxymethyl)phenol

There total 7 articles about 4-bromo-3-(hydroxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ (2-bromo-5-hydroxybenzene)methanol (2737-20-4)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; ethanol; hydrogen; C₃₁H₃₀FeNOP; isopropyl alcohol; lithium tert-butoxide; at 20 ℃; for 12h; under 750.075 Torr;

Reference yield: 96.0%

2-bromo-5-hydroxybenzaldehyde (2973-80-0) → (2-bromo-5-hydroxybenzene)methanol (2737-20-4)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

Reference yield: 87.0%

3-Hydroxybenzyl alcohol (620-24-6) → (2-bromo-5-hydroxybenzene)methanol (2737-20-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; Solvent; Inert atmosphere; Cooling with ice;

upstream raw materials:

3-Hydroxybenzyl alcohol

2-bromo-5-hydroxybenzaldehyde

ethyl-3-hydroxybenzoate

3-Carboxyphenol

Refernces

• 1、 -. "PNO ligand containing planar chiral ferrocene and application thereof". Paragraph 0114-0118. . Retrieved 2021/06/21.
• 2、 -. "A substituted boron-containing compounds and pharmaceutical compositions containing the compounds (by machine translation)". Paragraph 0128; 0130; 0131; 0132; 0133. . Retrieved 2019/02/02.