4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile

Base Information

• Chemical Name: 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile
• CAS No.: 906673-45-8
• Molecular Formula: C14H10BrNO2
• Molecular Weight: 304.143
• Mol file: 906673-45-8.mol

Synonyms:4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile;2-bromo-5-(4-cyanophenoxy)benzyl alcohol

Chemical Property of 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile

Chemical Property:

• Boiling Point: 447.6±45.0 °C(Predicted)
• PKA: 13.96±0.10(Predicted)
• PSA: 53.25000
• Density: 1.57±0.1 g/cm3(Predicted)
• LogP: 3.60538
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile is a useful research chemical.

Technology Process of 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile

There total 8 articles about 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-bromo-3-formaldehydephenoxy)benzonitrile (906673-54-9) → 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (906673-45-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2009.03.007

Reference yield: 96.2%

(2-bromo-5-hydroxybenzene)methanol (2737-20-4) + 4-fluorobenzonitrile (1194-02-1,143234-87-1) → 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (906673-45-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃;

Reference yield: 95.0%

4-(3-(hydroxymethyl)phenoxy)benzonitrile (888967-63-3) → 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile (906673-45-8)

Guidance literature:

With N-Bromosuccinimide; toluene-4-sulfonic acid; In acetonitrile; at 25 ℃; for 6h; Reagent/catalyst; Solvent; Reflux;

upstream raw materials:

4-(4-bromo-3-formaldehydephenoxy)benzonitrile

2-bromo-5-hydroxybenzaldehyde

4-fluorobenzonitrile

(2-bromo-5-hydroxybenzene)methanol

Downstream raw materials:

AN₂₇₂₈

C₁₉H₁₈BrNO₃

Refernces

• 1、 -. "INTERMEDIATES AND PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF A TOPICAL ANTI-INFLAMMATORY AGENT". . . Retrieved 2019/08/20.
• 2、 -. "A method for preparing [...]". Paragraph 0055; 0056; 0057; 0058; 0059; 0060; 0061-0063. . Retrieved 2019/04/14.