2-Pentyloxybenzoic acid methyl ester

Base Information

• Chemical Name: 2-Pentyloxybenzoic acid methyl ester
• CAS No.: 21018-10-0
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 21018-10-0.mol

Synonyms:2-Pentyloxybenzoic acid methyl ester

Chemical Property of 2-Pentyloxybenzoic acid methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 3.04220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pentyloxybenzoic acid methyl ester

There total 3 articles about 2-Pentyloxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

→ methyl 2-(pentyloxy)benzoate (21018-10-0)

Guidance literature:

Reference yield:

1-Bromopentane (110-53-2) + methyl salicylate (119-36-8,8024-54-2) → methyl 2-(pentyloxy)benzoate (21018-10-0)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 48h; Heating;

DOI:10.1021/jm00062a011

Reference yield:

1-Chloropentane (543-59-9) + methyl salicylate (119-36-8,8024-54-2) → methyl 2-(pentyloxy)benzoate (21018-10-0)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) THF, 0 deg C, 2.) reflux, 4 h;

DOI:10.1021/jm00396a013

upstream raw materials:

1-Chloropentane

methyl salicylate

1-Bromopentane

Downstream raw materials:

2-pentyloxy-benzoic acid anilide

2-Pentyloxy-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide

2-(pentyloxy)benzoic acid

2-pentyloxy-benzoic acid butylamide

Refernces

• 1、 Coates, William J.,Connolly, Brendan,Dhanak, Dashyant,Flynn, Sean T.,Worby, Angela. "Cyclic Nucleotide Phosphodiesterase Inhibition by Imidazopyridines: Analogues of Sulmazole and Isomazole as Inhibitors of the cGMP Specific Phosphodiesterase". . p. 1387 - 1392. Retrieved 2007/10/02.