tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate

Base Information

Chemical Name:tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate
CAS No.:371775-73-4
Molecular Formula:C₂₈H₃₈FN₃O₆S
Molecular Weight:563.691
Hs Code.:
Mol file:371775-73-4.mol

Synonyms:tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate;(4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[(Methylsulfonyl)aMino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester

Suppliers and Price of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate
1mg
$ 110.00

Medical Isotopes, Inc.
tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate
1 mg
$ 860.00

American Custom Chemicals Corporation
TERT-BUTYL-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-MESYLAMINOPYRIMIDIN-5-YL]-(3R,5S)-ISOPROPYLIDINE-(E)-6-HEPTENOATE 95.00%
5MG
$ 503.88

Total 3 raw suppliers

Chemical Property of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:674.873°C at 760 mmHg
Flash Point:361.95°C
Density:1.229g/cm³
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate

There total 8 articles about tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-mesylaminopyrimidin-5-yl]-(3R,5S)-isopropylidine-(E)-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

: 371775-72-3
C₂₇H₂₇FN₃O₃PS

: 124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 371775-73-4
C₂₈H₃₈FN₃O₆S

Guidance literature:: C₂₇H₂₇FN₃O₃PS; With sodium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 0.333333h;

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; In tetrahydrofuran; at -60 - 10 ℃; for 0.25h;

Reference yield:

: C₃₃H₃₂FN₃O₂PS⁽¹⁺⁾*Cl^(1-)

: 124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 371775-73-4
C₂₈H₃₈FN₃O₆S

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;

Reference yield:

: C₂₂H₂₃ClFN₃O₂S

: 371775-73-4
C₂₈H₃₈FN₃O₆S

Guidance literature:: Multi-step reaction with 3 steps

1: palladium(II) hydroxide; hydrogen / ethanol / 10 h / 20 °C

2: toluene / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With hydrogen; palladium(II) hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;