124752-23-4

Basic information

• Product Name: tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate
• Synonyms: TERT-BUTYL (3R,5S)-6-OXO-3,5-O-ISO-PROPYLIDENE-3,5-DIHYDROXYHEXANOATE;(4R-cis)-6-Formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester;tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate;(3R,5S)-6-Oxo-3,5-O-diisopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester;tert-Butyl (4R-cis)-6-ForMaldehydel-2,2-diMethyl-1,3-dioxane-4-acetate DISCONTINUED. See H946660;(4R-Cis)-6-ForMaldehydel-2,2-diMethyl-1,3-dioxane-4-acetic acid,1,1-diMenthylethyl ester;tert-Butyl [(4R, 6S)-6-forMyl-2,2-diMethyl-1,3-dioxan-4-yl]acetate;(4R-cis)-6-forMaldehydel-2,2-diMethyl-1, 3-dioxane
• CAS NO: 124752-23-4
• Molecular Formula: C₁₃H₂₂O₅
• Molecular Weight: 258.31
• EINECS: 1308068-626-2
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediates;INTERMEDIATES OF ROSUVASTATIN
• Mol File: 124752-23-4.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 320.344 °C at 760 mmHg
• Flash Point: 140.583 °C
• Appearance: /
• Density: 1.073 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate(124752-23-4)
• EPA Substance Registry System: tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate(124752-23-4)

Safety Data

• Hazardous Substances Data: 124752-23-4(Hazardous Substances Data)

Usage

Uses

tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate can be used as intermediate used in the synthesis of statins.

InChI:InChI=1/C13H22O5/c1-12(2,3)18-11(15)7-9-6-10(8-14)17-13(4,5)16-9/h8-10H,6-7H2,1-5H3/t9-,10+/m1/s1

Upstream product

• 79-37-8 oxalyl dichloride 
• 124655-09-0 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate 
• 123185-85-3 tert-butyl cis-3,5-dihydroxy-7-phenylhept-6-enoate 
• 1694-31-1 tert-butyl acetoacetate 
• 123185-86-4 t-butyl (3S^*,5R^*,6E)-7-phenyl-3,5-isopropylidenedioxy-6-heptenoate 
• 74530-57-7 tert-butyl 4-bromoacetoacetate 
• 74530-56-6 tert-butyl 4-chloroacetoacetate 
• 1378943-63-5 C₂₉H₄₀FN₃O₆S 
• 154026-93-4 1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate 
• 154026-92-3 Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate 
• 521973-99-9 tert-butyl 2-((6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 154026-95-6 (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 
• 154026-94-5 (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester 
• 406680-96-4 tert-butyl (5S)-6-chloro-3,5-dihydroxyhexanoate 

Downstream Products

• 855249-03-5 (6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methoxybenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester 
• 855249-04-6 (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester 
• 118845-49-1 trans-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>tetrahydro-4-hydroxy-2H-pyran-2-one 
• 289042-12-2 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester 
• 855250-17-8 ((4R,6S)-6-{2-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-(2-pyridin-3-ylethylcarbamoyl)-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester 
• 371775-73-4 C₂₈H₃₈FN₃O₆S 
• 1207460-26-1 tert-butyl ((E)-(6-{2-chloro-[4-(4'-fluorophenyl)-6-isopropyl]-pyrimidin-5-yl}-vinyl)-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetate 
• 1333229-48-3 C₄₀H₄₅FN₂O₅ 
• 1333229-49-4 C₄₀H₄₅FN₂O₅ 
• 147526-32-7 pitavastatin calcium salt 
• 500731-91-9 tert-butyl 2-((4R,6S)-6-((E)-2-(3-(4-fluorophenyl)-1-isopropylindol-2-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 

Relevant articles and documents

A new way to tert-Butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a key intermediate of atorvastatin synthesis

A new synthesis of tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a key intermediate of the synthesis of an effective HMG-CoA reductase inhibitor atorvastatin, is described. The synthesis is based on the Henry reaction of nitromethane and tert-butyl [(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl] acetate. The formed nitroaldol was then O-acetylated and the sodium borohydride reduction of the intermediate provided tert-butyl [(4R,6R)-2,2-dimethyl-6-nitroethyl-1,3-dioxan-4-yl] acetate. Catalytic hydrogenation of the nitro group led to the title compound.

Method for preparing rosuvastatin side chain through oxidation in continuous flow micro-channel reactor

The invention relates to a method for preparing a rosuvastatin side chain through oxidation in a continuous flow micro-channel reactor. In the micro-channel reactor, a compound D6 is oxidized by sodium hypochlorite to synthesize a compound D7; the reaction flow is shown in the specification. The method solves the problems that existing preparation methods are long in reaction time, high in requirements on reaction condition, incapable of continuous product, high in cost and the like. The method has the advantages of simplicity and safety in operation, short reaction time, high product conversion rate, high product purity and the like, materials after reaction can be directly subjected to aftertreatment operation, aftertreatment is simple, the product yield is 92% or above, the product purity is 99.8%, and the method is particularly suitable for industrial large-scale production.

Rosuvastatin calcium intermediate, preparation method thereof and application of intermediate

The invention discloses a rosuvastatin calcium intermediate, a preparation method thereof and an application of the intermediate. The synthesis process of the intermediate is environmentally friendly,simple and convenient to operate and low in EHS (environment health safety) risk, raw materials are easily available, and used chemical reagents are low in toxicity and low in price, so that the synthesis process of the intermediate is a green synthesis process suitable for industrial production. In addition, the intermediate is applied to synthesis of rosuvastatin calcium and key intermediates thereof, has short route and high yield, effectively reduces the industrial production cost of rosuvastatin calcium, and has a higher industrial application prospect.