N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE

Base Information

• Chemical Name: N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE
• CAS No.: 903581-02-2
• Molecular Formula: C17H19ClFNO4S
• Molecular Weight: 387.86
• Hs Code.: 2922199090
• Mol file: 903581-02-2.mol

Synonyms:N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE

Chemical Property of N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE

Chemical Property:

• Vapor Pressure: 2E-11mmHg at 25°C
• Boiling Point: 532.6°C at 760 mmHg
• Flash Point: 275.9°C
• PSA: 73.01000
• Density: 1.324g/cm³
• LogP: 5.22670

Purity/Quality:

95% ^*data from raw suppliers

[1-(5-CHLORO-2,3-DIMETHOXY-PHENYL)-ETHYL]-(5-FLUORO-2-METHANESULFONYL-PHENYL)-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE

There total 2 articles about N-(1-(5-CHLORO-2,3-DIMETHOXYPHENYL)ETHYL)-5-FLUORO-2-(METHYLSULFONYL)BENZENAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylthio)phenyl]amine (1187658-86-1) → N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylsulfonyl)phenyl]amine (903581-02-2)

Guidance literature:

With Oxone; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield: 51.1%

1-(5-chloro-2,3-dimethoxy-phenyl)-ethylamine (903581-03-3) + 2,4-difluoro-1-(methylsulfonyl)benzene (236739-02-9) → N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylsulfonyl)phenyl]amine (903581-02-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110 ℃; for 18h; Product distribution / selectivity;

Reference yield: 89.0%

piperazine (110-85-0) + N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylsulfonyl)phenyl]amine (903581-02-2) → [1-(5-chloro-2,3-dimethoxy-phenyl)-ethyl]-(2-methanesulfonyl-5-piperazin-1-yl-phenyl)-amine (903580-16-5,903631-09-4,903631-10-7)

Guidance literature:

In ISOPROPYLAMIDE; at 130 ℃; for 5h;

upstream raw materials:

1-(5-chloro-2,3-dimethoxy-phenyl)-ethylamine

2,4-difluoro-1-(methylsulfonyl)benzene

N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylthio)phenyl]amine

Downstream raw materials:

[1-(5-chloro-2,3-dimethoxy-phenyl)-ethyl]-(2-methanesulfonyl-5-piperazin-1-yl-phenyl)-amine