236739-02-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Difluorophenyl Methyl Sulfone is used as a reactant for the synthesis of BMS-903452, an antidiabetic clinical candidate. 2,4-DIFLUOROPHENYLMETHYLSULFONE targets GPR119, a G-protein coupled receptor, which plays a crucial role in glucose homeostasis and insulin secretion. By modulating GPR119, BMS-903452 has the potential to improve blood glucose control and provide a novel treatment option for patients with diabetes.
In the synthesis of BMS-903452, 2,4-Difluorophenyl Methyl Sulfone serves as a vital building block, contributing to the overall structure and biological activity of the final product. Its unique chemical properties enable the formation of specific bonds and interactions that are essential for the compound's therapeutic effects. As a result, 2,4-Difluorophenyl Methyl Sulfone plays a significant role in the development of innovative antidiabetic drugs, offering new possibilities for the treatment of diabetes and its associated complications.

InChI:InChI=1/C7H6F2O2S/c1-12(10,11)7-3-2-5(8)4-6(7)9/h2-4H,1H3

Upstream product

• 558-25-8 methyl fluorosulfonate 
• 372-18-9 1,3-Difluorobenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 130922-40-6 (2,4-difluorophenyl)(methyl)sulfane 
• 1996-44-7 2,4-difluorothiophenol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 903581-19-1 N-(5-fluoro-2-(methylsulfonyl)phenyl)chroman-4-amine 
• 903581-00-0 C₁₆H₁₅F₄NO₂S 
• 903580-15-4 N-(5-fluoro-2-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydronaphthalen-1-amine 
• 845617-24-5 1-[3-fluoro-4-(methylsulfonyl)phenyl]piperazine 
• 1339944-48-7 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(3-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 
• 1339944-44-3 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one 
• 1339944-49-8 tert-butyl 4-(5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate 
• 1095538-75-2 C₁₆H₂₃FN₂O₄S 
• 903581-05-5 N-(5-fluoro-2-(methylsulfonyl)phenyl)naphthalen-1-amine 
• 903581-31-7 5-fluoro-N-(1-(5-fluoro-2-methoxy-3-methylphenyl)ethyl)-2-(methylsulfonyl)benzenamine 
• 903581-26-0 5-fluoro-N-(1-(5-fluoro-2-methoxy-3-chlorophenyl)ethyl)-2-(methylsulfonyl)benzenamine 
• 903581-18-0 6-chloro-N-(5-fluoro-2-(methylsulfonyl)phenyl)chroman-4-amine 
• 903581-16-8 N-(5-fluoro-2-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydro-5,8-dimethoxynaphthalen-1-amine 
• 903581-53-3 N-(1-(6-chloro-2,3-dihydrobenzo[b][1,4]dioxin-8-yl)ethyl)-5-fluoro-2-(methylsulfonyl)benzenamine 

Relevant academic research and scientific papers

Highly atom-economic, catalyst- and solvent-free oxidation of sulfides into sulfones using 30% aqueous H2O2

Highly atom-efficient oxidation of sulfides into sulfones under solvent- and catalyst-free reaction conditions using a 30% aqueous solution of H 2O2 at 75 °C is reported. A structurally diverse set of phenyl alkyl-, phenyl benzyl-, benzyl alkyl-, dialkyl-, heteroaryl alkyl- and cyclic sulfides were transformed into sulfones regardless of the aggregate state and electronic nature of the substituents. In spite of the heterogeneous reaction mixtures throughout the work, no difficulties with stirring and reaction progress were noted. In numerous cases, only 10 mol% excess of H 2O2 was used, thus contributing considerably to the high atom economy of the process. Some solid substrates required a variable excess of hydrogen peroxide; however, the reactions were performed strictly without organic solvents. The transformation was demonstrated to be amenable for scale-up with both liquid and solid sulfides. In addition, isolation and purification of the crude products can be simply done with only filtration and crystallization.

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Methanesulfonylation of deactivated aromatics with superelectrophilic CH3so2F·3SbF5 and (CH3so2)2O-2CF3so 3H/B(O3SCF3)3 systems

Methanesulfonylation of various deactivated arenes, including tri- and tetrafluorobenzenes, was achieved in good yield under mild conditions using superelectrophilic CH3SO2F/3SbF5 and (CH3SO2O)2O/2CF3SO 3H-B(O3SCF3)3 reagent systems. 1998 MAHK "Hayka/Interperiodica".