236739-02-9

Basic information

• Product Name: 2,4-DIFLUOROPHENYLMETHYLSULFONE
• Synonyms: 2,4-Difluoro-1-(methylsulfonyl)benzene
• CAS NO: 236739-02-9
• Molecular Formula: C₇H₆F₂O₂S
• Molecular Weight: 192.19
• Mol File: 236739-02-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 60-61°C
• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: /
• Density: 1.376 g/cm³
• Vapor Pressure: 0.00388mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIFLUOROPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROPHENYLMETHYLSULFONE(236739-02-9)
• EPA Substance Registry System: 2,4-DIFLUOROPHENYLMETHYLSULFONE(236739-02-9)

Safety Data

• Hazardous Substances Data: 236739-02-9(Hazardous Substances Data)

Usage

Uses

2,4-Difluorophenyl Methyl Sulfone is used as a reactant in the synthesis of BMS-903452 as an antidiabetic clinical candidate targeting GPR119.

InChI:InChI=1/C7H6F2O2S/c1-12(10,11)7-3-2-5(8)4-6(7)9/h2-4H,1H3

Upstream product

• 558-25-8 methyl fluorosulfonate 
• 372-18-9 1,3-Difluorobenzene 
• 1996-44-7 2,4-difluorothiophenol 
• 124-63-0 methanesulfonyl chloride 
• 7143-01-3 Methanesulfonic anhydride 
• 130922-40-6 (2,4-difluorophenyl)(methyl)sulfane 

Downstream Products

• 903581-19-1 N-(5-fluoro-2-(methylsulfonyl)phenyl)chroman-4-amine 
• 903581-07-7 C₁₅H₁₆FNO₂S 
• 903581-00-0 C₁₆H₁₅F₄NO₂S 
• 903581-09-9 N-(1-(3,5-dichlorophenyl)ethyl)-5-fluoro-2-(methylsulfonyl)benzenamine 
• 903581-45-3 N-(3,5-dichlorobenzyl)-5-fluoro-2-(methylsulfonyl)benzenamine 
• 903580-15-4 N-(5-fluoro-2-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydronaphthalen-1-amine 
• 903581-24-8 N-(5-fluoro-2-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydro-2-methylnaphthalen-1-amine 
• 903580-96-1 C₁₇H₁₉ClFNO₄S 
• 903580-98-3 C₁₆H₁₇ClFNO₃S 
• 903581-02-2 N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-N-[5-fluoro-2-(methylsulfonyl)phenyl]amine 
• 903581-53-3 N-(1-(6-chloro-2,3-dihydrobenzo[b][1,4]dioxin-8-yl)ethyl)-5-fluoro-2-(methylsulfonyl)benzenamine 
• 903581-16-8 N-(5-fluoro-2-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydro-5,8-dimethoxynaphthalen-1-amine 
• 903581-18-0 6-chloro-N-(5-fluoro-2-(methylsulfonyl)phenyl)chroman-4-amine 
• 903581-26-0 5-fluoro-N-(1-(5-fluoro-2-methoxy-3-chlorophenyl)ethyl)-2-(methylsulfonyl)benzenamine 

Relevant articles and documents

COMPOUNDS

The present invention relates to a compound of formula (Ia), or a pharmaceutically acceptable salt or hydrate thereof, wherein: the group X-Y is -NHSO2- or -SO2NH-; R1 is H or alkyl; R2 is selected from COOH and a tetrazolyl group; R3 is selected from H, Cl and alkyl; R4 is selected from H, Cl and F; R5 is selected from H, alkyl, alkynyl, alkenyl, haloalkyl, SO2-alkyl, Cl, alkoxy, OH, CN, hydroxyalkyl, alkylthio, heteroaryl, cycloalkyl, heterocycloalkyl and haloalkoxy; R6 is H; R7 is selected from H, CN, haloalkyl, Cl, F, SO2-alkyl, SO2NR13R14, optionally substituted heteroaryl and alkyl; R8 is selected from H, alkyl, haloalkyl and halo; R9 is H, C1-C3-alkyl, or halo; R10 and R11, together with the nitrogen to which they are attached, form an azepanyl group, wherein (a) said azepanyl group is substituted by one or more substituents, or (b) one or two carbons in said azepanyl group are replaced by a group selected from O, NH, S and CO, and said azepanyl group is optionally further substituted; or R10 and R11, together with the nitrogen to which they are attached, form an azetidinyl, pyrrolidinyl or piperidinyl group wherein (a) said azetidinyl, pyrrolidinyl or piperidinyl group is substituted by one or more substituents, or (b) one or two carbons in said azetidinyl, pyrrolidinyl or piperidinyl group are replaced by a group selected from NH, S and CO; or R10 and R11, together with the nitrogen to which they are attached, form an 8, 9 or 10-membered bicyclic heterocycloalkyl group, wherein one or two carbons in the bicyclic heterocycloalkyl ring are optionally replaced by a group selected from O, NH, S and CO, and said bicyclic heterocycloalkyl group is optionally substituted; or R10 and R11, together with the nitrogen to which they are attached, form a 6 to 12-membered bicyclic group containing a spirocyclic carbon atom, wherein one or two carbons in the bicyclic group are optionally replaced by a group selected from O, NH, S and CO, and said bicyclic group is optionally substituted, or said bicyclic group is optionally fused to a 5 or 6-membered aryl or heteroaryl group; R13 and R14 are each independently H or alkyl. Further aspects of the invention relate to such compounds for use in the field of immune-oncology and related applications.

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.