N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine

Base Information

Chemical Name:N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine
CAS No.:388082-81-3
Molecular Formula:C28H25ClFN5O3S2.2ClH
Molecular Weight:598.122
Hs Code.:
European Community (EC) Number:636-788-3
Nikkaji Number:J1.859.982A
Wikidata:Q27165111
Pharos Ligand ID:3DC2YKJKQ3JC
ChEMBL ID:CHEMBL453376
Mol file:388082-81-3.mol

Synonyms:GW 583340;GW-583340;GW583340

Suppliers and Price of N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GW-583340 DIHYDROCHLORIDE 95.00%
50MG
$ 1381.33

American Custom Chemicals Corporation
GW-583340 DIHYDROCHLORIDE 95.00%
10MG
$ 733.72

Total 4 raw suppliers

Chemical Property of N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine

Chemical Property:

Vapor Pressure:2.9E-27mmHg at 25°C
Melting Point:259.8-262.4 °C(lit.)
Boiling Point:816.5°C at 760 mmHg
Flash Point:447.6°C
PSA：142.72000
LogP:9.15130
Storage Temp.:2-8°C
Solubility.:DMSO: 9 mg/mL
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:597.1071379
Heavy Atom Count:40
Complexity:902

Purity/Quality:

97% ^*data from raw suppliers

GW-583340 DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Technology Process of N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine

There total 12 articles about N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 388082-81-3
(4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: propan-2-ol

2: Pd(PPh₃)2Cl₂

3: NBS / CH₂Cl₂

4: dimethylformamide / 70 °C

5: NaOH / methanol

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 4: Hantzsch reaction;
DOI:10.1016/S0960-894X(02)01047-8

Reference yield:

: 443883-07-6
N-{4-[(3-fluorobenzyloxy)]-chlorophenyl}-6-[2-({[2-(methanesulphonyl)ethyl]-[trifluoroacetyl]amino}methyl)-1,3-thiazol-4-yl]-(quinazolin-4-yl)-amine

: 388082-81-3
(4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0960-894X(02)01047-8

Reference yield:

: 231278-20-9
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

: 388082-81-3
(4-(3-fluoro-benzyloxy)-3-chlorophenyl)-(6-(2-((2-methanesulphonyl-ethylamino)methyl)-thiazol-4-yl)-quinazolin-4-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(PPh₃)2Cl₂

2: NBS / CH₂Cl₂

3: dimethylformamide / 70 °C

4: NaOH / methanol

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; In methanol; dichloromethane; N,N-dimethyl-formamide; 3: Hantzsch reaction;
DOI:10.1016/S0960-894X(02)01047-8