N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

Base Information

Chemical Name:N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
CAS No.:231278-20-9
Molecular Formula:C21H14ClFIN3O
Molecular Weight:505.718
Hs Code.:2933990090
European Community (EC) Number:607-200-2
DSSTox Substance ID:DTXSID10436351
Nikkaji Number:J1.696.966D
Wikidata:Q72450747
Mol file:231278-20-9.mol

Synonyms:231278-20-9;N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine;N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine;N-[3-Chloro-4-(3-Fluorobenzyloxy)-Phenyl]-6-Iodoquinazolin-4-Amine;n-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine;N-[3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL]-6-IODOQUINAZOLIN-4-AMINE;N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine;N-{3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-iodoquinazolin-4-amine;MFCD09998827;6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline;4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-;N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodoquinazolin-4-amine;N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine;C21H14ClFIN3O;SCHEMBL141514;DTXSID10436351;BCP22642;AKOS015848952;N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-4-quinazolinamine;AC-8334;CS-W011494;GS-3803;SB18203;BP-27845;SY053116;AM20090640;C2965;FT-0658071;A816573;5H-Pyrrolo[3,4-d]pyrimidine,4-amino-6,7-dihydro;Q-101357;4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-iodoquinazoline;N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodo-4-quinazolinamine;N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-iodoquinazolin-4-amine;N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazoline-4-amine;[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-amine;[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-(6-iodoquinazo-lin-4-yl)amine;N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine;N-[3-chloranyl-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodanyl-quinazolin-4-amine

Suppliers and Price of N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-4-quinazolinamine
500mg
$ 55.00

TCI Chemical
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline >98.0%(HPLC)(T)
1g
$ 38.00

TCI Chemical
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline >98.0%(HPLC)(T)
5g
$ 167.00

Medical Isotopes, Inc.
N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amine
10 mg
$ 875.00

Matrix Scientific
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine 97%
5g
$ 75.00

Matrix Scientific
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine 97%
25g
$ 194.00

Matrix Scientific
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine 97%
1g
$ 25.00

Crysdot
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine 97%
25g
$ 201.00

Chemenu
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine 97%
25g
$ 199.00

Chemcia Scientific
[3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-amine 95%
25 G
$ 440.00

Total 182 raw suppliers

Chemical Property of N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

Chemical Property:

Appearance/Colour:yellow solid
Vapor Pressure:0mmHg at 25°C
Melting Point:222-224 °C
Refractive Index:1.724
Boiling Point:581.326 °C at 760 mmHg
PKA:5.04±0.50(Predicted)
Flash Point:305.375 °C
PSA：47.04000
Density:1.691 g/cm³
LogP:6.42250
Storage Temp.:-20°C Freezer
Sensitive.:Light Sensitive
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
Water Solubility.:Slightly soluble in water.
XLogP3:6.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:504.98542
Heavy Atom Count:28
Complexity:504

Purity/Quality:

99% ^*data from raw suppliers

N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-4-quinazolinamine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)I)Cl
Description N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs.
Uses Lapatinib intermediate 4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline is used as an organic chemical synthesis intermediate.

Technology Process of N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

There total 22 articles about N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 903597-10-4
N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine

: 202197-26-0
3-chloro-4-(3-fluorobenzyloxy)aniline

: 231278-20-9
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

Guidance literature:: With acetic acid; In N,N-dimethyl-formamide; at 130 ℃; for 1h;

Reference yield: 98.0%

: 202197-26-0
3-chloro-4-(3-fluorobenzyloxy)aniline

: 231278-20-9
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

Guidance literature:: 6-iodo-1H-quinazolin-4-one; With triethylamine; trichlorophosphate; In aqueous sodium hydroxide; toluene; at 20 - 80 ℃; for 3h;

3-chloro-4-(3-fluorobenzyloxy)aniline; In toluene; acetonitrile; at 20 - 80 ℃; for 2h;