1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE

Base Information

• Chemical Name: 1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE
• CAS No.: 154777-21-6
• Molecular Formula: C11H15NO
• Molecular Weight: 177.2429
• Mol file: 154777-21-6.mol

Synonyms:1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE;1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE-HCL

Chemical Property of 1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE

Chemical Property:

• PSA: 21.26000
• LogP: 2.44850
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

95-99% ^*data from raw suppliers

1-((2R)Pyrrolidin-2-yl)-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE

There total 42 articles about 1-((2R)PYRROLIDIN-2-YL)-4-METHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C11H15NO*ClH (1227798-75-5,1049740-97-7) → (R)-(+)-2-(4-methoxyphenyl)pyrrolidine (154777-21-6)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 0.166667h; optical yield given as %ee;

DOI:10.1039/b925209f

Reference yield: 99.0%

C11H15NO*ClH (1227798-73-3,1049740-97-7) → (S)-(–)-2-(4-methoxyphenyl)pyrrolidine (1217825-97-2,154777-21-6)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 0.166667h; optical yield given as %ee;

DOI:10.1039/b925209f

Reference yield: 99.0%

N-(3-chloropropyl)-(4-methoxyphenyl)methanimine → 2-(4-methoxyphenyl)pyrrolidine (74190-66-2,154777-21-6)

Guidance literature:

With lithium; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jo010419n

upstream raw materials:

4-(4-methoxy-phenyl)-4-oxo-butyronitrile

4-methoxy-benzaldehyde

5-(4-methoxyphenyl)pyrrolidin-2-one

4-amino-4-(4-methoxyphenyl)butan-1-ol

Downstream raw materials:

(S)-(–)-2-(4-methoxyphenyl)pyrrolidine