Technology Process of 2-(4-AMino-3-iodophenyl)-N-MethylethanesulfonaMide
There total 1 articles about 2-(4-AMino-3-iodophenyl)-N-MethylethanesulfonaMide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-amino-phenyl)ethanesulfonic acid methylamide;
With
sodium hydrogencarbonate;
In
water;
for 0.5h;
With
iodine;
In
water;
at 5 - 20 ℃;
for 6h;
DOI:10.3762/bjoc.5.46
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 1.5 h / 25 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.2: 0.5 h / 25 °C
With
copper(l) iodide; ethanol; potassium tert-butylate; lithium chloride; potassium hydroxide;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
2.2: Sonogashira Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dichloromethane / 1.5 h / 25 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.2: 0.5 h / 25 °C
5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
5.2: 10 - 15 °C / pH 8
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
6.2: 10 °C / pH 7.5 - 8.5
With
copper(l) iodide; ethanol; potassium tert-butylate; hydrogen; acetic acid; trifluoroacetic acid; lithium chloride; potassium hydroxide;
palladium 10% on activated carbon;
In
1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;
2.2: Sonogashira Coupling / 5.1: Aldol Condensation;
