98623-16-6

Usage

InChI:InChI=1/C9H14N2O2S/c1-11-14(12,13)7-6-8-2-4-9(10)5-3-8/h2-5,11H,6-7,10H2,1H3

Downstream Products

• 954424-55-6 2-(4-amino-3-bromo-phenyl)-ethanesulfonic acid methylamide 
• 1200070-42-3 2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide 
• 143388-64-1 naratriptan hydrochloride 
• 98623-50-8 N-Methyl-1H-indole-5-ethanesulphonamide 
• 121679-13-8 naratriptan 
• 121679-20-7 N-methyl-2-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide 
• 1268265-90-2 N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide 
• 1268265-93-5 2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide 
• 1268265-95-7 N-[4-(2-{methylsulfamoyl}ethyl)-2-{2-(trimethylsilanyl)ethynyl}phenyl]acetamide 
• 1268265-97-9 2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide 
• 1268265-99-1 N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide 
• 1268266-01-8 2-(4-benzylamino-3-ethynylphenyl)ethanesulfonic acid methylamide 
• 894351-85-0 2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide 
• 894351-86-1 2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide 

Relevant academic research and scientific papers

Pd/C-Mediated synthesis of indoles in water

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,s 5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

INHIBITORS OF C-FMS KINASE

The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

PROCESS FOR PREPARING NARATRIPTAN HYDROCHLORIDE

A process for preparing naratriptan hydrochloride, N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulphonamide hydrochloride having formula (I).

5-substituted-3-aminoalkyl indole derivatives for migraine

Indole derivatives are disclosed of the general formula (I): STR1 wherein R1 is hydrogen, C1-6 alkyl or C3-6 alkenyl; R2 is a hydrogen, C1-3 alkyl, C3-6 alkenyl, phenyl, phen(C1-4)alkyl or C5-7 cycloalkyl; R3 and R4 are hydrogen, C1-3 alkyl or propenyl groups or together form an aralkylidene group; Alk is C2 -C3 alkylene chain and A is C2 -C5 alkylene chain and its physiologically acceptable salts and solvates. The compounds may be prepared, for example, by cyclization of a compound of general formula (II): STR2 where Q is the group NR3 R4 or a protected derivative thereof or a leaving group and R1 l, R2, R3, R4, A and Alk are as defined for formula (I). The compounds have a selective vosoconstrictor action and are useful in treating pain such as migraine. The compounds may be formulated as pharmaceutical compositions in conventional manner, preferably for oral administration.