Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione

Base Information

Chemical Name:Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione
CAS No.:37043-04-2
Molecular Formula:C8H12N2O2
Molecular Weight:168.195
Hs Code.:
European Community (EC) Number:839-321-3
DSSTox Substance ID:DTXSID90441342
Mol file:37043-04-2.mol

Synonyms:Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione;37043-04-2;150284-51-8;hexahydro-6H-pyrido[1,2-a]pyrazine-1,4-dione;3,6,7,8,9,9a-Hexahydro-2H-pyrido[1,2-a]pyrazine-1,4-dione;MFCD10574833;hexahydro-pyrido[1,2-a]pyrazine-1,4-dione;octahydro-1H-pyrido[1,2-a]piperazine-1,4-dione;SCHEMBL3519708;DTXSID90441342;AC8655;AKOS004911440;AM807205;SY075318;CS-0451730;EN300-76314;A913859;Hexahydro-4H-pyrido[1,2-a]pyrazine-1,4(6H)-dione;Z1187847303

Suppliers and Price of Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione 95+%
1g
$ 772.00

Alichem
Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione
1g
$ 772.20

Total 2 raw suppliers

Chemical Property of Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:443.96°C at 760 mmHg
Flash Point:222.299°C
PSA：49.41000
Density:1.266g/cm³
LogP:-0.23600
XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:168.089877630
Heavy Atom Count:12
Complexity:227

Purity/Quality:

97% ^*data from raw suppliers

Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN2C(C1)C(=O)NCC2=O

Technology Process of Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione

There total 4 articles about Hexahydro-1H-pyrido[1,2-a]pyrazine-1,4(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 155346-54-6
[(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid

: 37043-04-2,150284-51-8
3,6,7,8,9,9a-hexahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione

Guidance literature:: With triethylamine; In methanol; Heating;
DOI:10.1021/jm00068a007

Reference yield:

: N-tBOC-pipecolinic acid

: 37043-04-2,150284-51-8
3,6,7,8,9,9a-hexahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et₃N / 24 h / Ambient temperature

2: 1 h / Ambient temperature

3: 55 percent / Et₃N / methanol / Heating

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol;
DOI:10.1021/jm00068a007

Reference yield:

: 2,2-Dimethyl-propionic acid 2-(methoxycarbonylmethyl-carbamoyl)-piperidin-1-yl ester

: 37043-04-2,150284-51-8
3,6,7,8,9,9a-hexahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1 h / Ambient temperature

2: 55 percent / Et₃N / methanol / Heating

With triethylamine; In methanol;
DOI:10.1021/jm00068a007