2-Chloro-5,6,7,8-tetrahydro-8-quinolinol

Base Information

• Chemical Name: 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol
• CAS No.: 130861-73-3
• Molecular Formula: C9H10ClNO
• Molecular Weight: 183.6348
• Hs Code.: 2933499090
• Mol file: 130861-73-3.mol

Synonyms:2-Chloro-5,6,7,8-tetrahydro-8-quinolinol;2-Chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline;2-Chloro-5,6,7,8-tetrahydroquinolin-8-ol

Chemical Property of 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol

Chemical Property:

• Vapor Pressure: 6.14E-05mmHg at 25°C
• Melting Point: 53-54℃
• Boiling Point: 331.6°C at 760 mmHg
• Flash Point: 154.4°C
• PSA: 33.12000
• Density: 1.326g/cm³
• LogP: 2.10470

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2-Chloro-5,6,7,8-tetrahydroquinolin-8-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol

There total 14 articles about 2-Chloro-5,6,7,8-tetrahydro-8-quinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-chloro-8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinoline (1351935-49-3) → 2-chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline (130861-73-3)

Guidance literature:

With 4,4'-bipyridine; (phthalocyaninato)iron(II); oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 80 ℃; for 16h; under 3000.3 Torr; Pressure; Autoclave;

Reference yield: 90.0%

2-chloro-5,6,7,8-tetrahydroquinolin-8-yl acetate (130861-72-2) → 2-chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline (130861-73-3)

Guidance literature:

With potassium carbonate; In methanol; for 5h; Ambient temperature;

DOI:10.1021/ja00001a027

Reference yield: 86.0%

2-chloro-5,6,7,8-tetrahydroquinolin-8-one (129337-86-6) → 2-chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline (130861-73-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 5h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7dt01720k

upstream raw materials:

2-chloro-5,6,7,8-tetrahydroquinolin-8-yl acetate

2-chloro-5,6,7,8-tetrahydroquinoline N-oxide

2-chloro-5,6,7,8-tetrahydro-quinoline

2-hydroxy-5,6,7,8-tetrahydroquinoline

Downstream raw materials:

5,6,7,8-tetrahydroquinoline-8-ol

2-(1-(2,6-dimethylphenylimino)ethyl)-8-(2,6-dimethylphenylimino)-5,6,7-trihydroquinoline

2-chloro-8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinoline

1-[8-(4-methoxybenzyloxy)-5,6,7,8-tetrahydroquinolin-2-yl]ethanone