129337-86-6

Usage

Uses

Used in Organic Synthesis:
2-Chloro-6,7-dihydroquinolin-8(5H)-one is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for the creation of a wide range of derivatives, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-chloro-6,7-dihydroquinolin-8(5H)-one is utilized as a key component in the development of new drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as improved efficacy, selectivity, or reduced side effects.
Used in Agrochemicals:
2-Chloro-6,7-dihydroquinolin-8(5H)-one is employed as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, while also potentially reducing the environmental impact.
Used in Chemical Research:
2-chloro-6,7-dihydroquinolin-8(5H)-one is also used as a research tool in the field of chemistry, where it can help scientists understand the properties and reactivity of quinolinone-based structures. This knowledge can then be applied to the design of new compounds with tailored properties for various applications.

Upstream product

• 130861-73-3 2-chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline 
• 130861-72-2 2-chloro-5,6,7,8-tetrahydroquinolin-8-yl acetate 
• 100-46-9 benzylamine 
• 85031-42-1 N-benzyl-N-(cyclohex-1-enyl)acetamide 
• 4471-09-4 N-benzylcyclohexylimine 
• 108-94-1 cyclohexanone 
• 399042-37-6 6,7-dihydro-2-(2-pyridinethione-N-oxycarbonyl)-8(5H)-quinolinone 
• 75-62-7 Bromotrichloromethane 
• 107-06-2 1,2-dichloro-ethane 
• 21172-88-3 2-chloro-5,6,7,8-tetrahydro-quinoline 
• 54802-19-6 2-hydroxy-5,6,7,8-tetrahydroquinoline 
• 130861-71-1 2-chloro-5,6,7,8-tetrahydroquinoline N-oxide 

Downstream Products

• 1263563-90-1 [2,4,6-trimethyl-N-(2-chloro-5,6,7-trihydroquinolin-8-ylidene)phenylamino]nickel(II) dichloride 
• 1263563-92-3 [2,6-diethyl-4-methyl-N-(2-chloro-5,6,7-trihydroquinolin-8-ylidene)phenylamino]nickel(II) dichloride 
• 1263563-88-7 [2,6-dimethyl-N-(2-chloro-5,6,7-trihydroquinolin-8-ylidene)phenylamino]nickel(II) dichloride 
• 1374423-12-7 2-(2,6-dimethoxyphenyl)-5,6,7,8-tetrahydro-8-quinolone 
• 1374423-13-8 2-[2,6-bis(hex-5-enyloxy)phenyl]-5,6,7,8-tetrahydro-8-quinolone 
• 849643-01-2 2-methyl-6,7-dihydro-5H-quinolin-8-one 
• 130861-73-3 2-chloro-8-hydroxy-5,6,7,8-tetrahydroquinoline 
• 1373403-68-9 2-chloro-8-(2,4-dibenzhydryl-6-methylphenylimino)-5,6,7-trihydroquinoline 
• 1373403-75-8 2-chloro-8-(2,6-dibenzhydryl-4-methylphenylimino)-5,6,7-trihydroquinoline 
• 1373403-79-2 2-chloro-8-(2,6-dibenzhydryl-4-isopropylphenylimino)-5,6,7-trihydroquinoline 
• 1373403-71-4 2-chloro-8-(2-benzhydryl-4,6-dimethylphenylimino)-5,6,7-trihydroquinoline 
• 130861-82-4 7-benzylidene-2-chloro-5,6,7,8-tetrahydro-8-quinolone 
• 129363-21-9 2,12-Dichloro-7-phenyl-5,7,8,9-tetrahydro-6H-14-oxa-1,13-diaza-dibenzo[a,j]anthracene 

Relevant academic research and scientific papers

SBA-15 Supported 1-Methyl-2-azaadamanane N-Oxyl (1-Me-AZADO) as Recyclable Catalyst for Oxidation of Alcohol

Herein, we designed and synthesized an SBA-15 supported 1-methyl-2-azaadamanane N-oxyl (1-Me-AZADO) and investigated its catalytic performance for selective oxidation of alcohols under Anelli's conditions. The first example of immobilization of 1-Me-AZADO was very important to advance the oxgenation effectively because this supported N-oxyl has excellent catalytic activity for oxidation of alcohols to carbonyl compounds, and more importantly, it can be conveniently recovered and reused at least 6 times without significant effect on its catalytic efficiency.

Large-Scale Synthesis of 2-Chlorotetrahydroquinoline and 2-Chlorotetrahydroquinolin-8-one

An efficient large-scale preparation of 2-chlorotetrahydroquinoline with cyclohexanone and benzylamine as starting materials was developed and well optimized, in which benzyl-protected enamide was successfully cyclized and benzyl group was directly removed under Vilsmeier conditions. Azeotropic distillation provided 264 g of 2-chlorotetrahydroquinoline (79%) on a 2 mol scale of reaction without intermediate isolation. The downstream product 2-chlorotetrahydroquinolin-8-one was acquired through Boekelheide rearrangement, hydrolysis of acetate via NaBH 4reduction, and Anelli oxidation. With the developed procedure, the intermediates were not necessary to be isolated and 2-chlorotetrahydroquinolin-8-one was conveniently obtained with solvent slurry in 65% overall isolated yield in a four-step sequence.

IRAK4 INHIBITING AGENTS

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Multicyclic aromatic compounds and uses thereof

Multicyclic aromatic compounds useful as complexing agents having the general formula: Methods of complexing and quantitating a component in a sample such as urea or guanidine are also disclosed.