Technology Process of 7-Chloro-1,2,3,4-tetrahydro-[1,8]naphthyridine
There total 3 articles about 7-Chloro-1,2,3,4-tetrahydro-[1,8]naphthyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 7-chloro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate;
With
trifluoroacetic acid;
at 20 ℃;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
pH=9;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C
1.2: 1 h / 0 - 20 °C
2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / copper(l) iodide / hexane; tetrahydrofuran / 2.92 h / -78 - 10 °C
2.2: -10 - 20 °C / Reflux
3.1: trifluoroacetic acid / 20 °C
3.2: pH 9
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane; trifluoroacetic acid;
copper(l) iodide;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / copper(l) iodide / hexane; tetrahydrofuran / 2.92 h / -78 - 10 °C
1.2: -10 - 20 °C / Reflux
2.1: trifluoroacetic acid / 20 °C
2.2: pH 9
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; trifluoroacetic acid;
copper(l) iodide;
In
tetrahydrofuran; hexane;
