2-(4-Iodophenyl)acetamide

Base Information

• Chemical Name: 2-(4-Iodophenyl)acetamide
• CAS No.: 84863-81-0
• Molecular Formula: C8H8INO
• Molecular Weight: 261.06
• Hs Code.: 2924299090
• ChEMBL ID: CHEMBL156355
• DSSTox Substance ID: DTXSID00515720
• Wikidata: Q82376764
• Mol file: 84863-81-0.mol

Synonyms:2-(4-Iodophenyl)acetamide;84863-81-0;CHEMBL156355;4-iodoBenzeneacetamide;4-IODOPHENYLACETAMIDE;(4-iodophenyl)acetamide;SCHEMBL3882531;DTXSID00515720;RKJMVTJNBPMLGH-UHFFFAOYSA-N;BDBM50226174;BS-29529;FT-0722468

Chemical Property of 2-(4-Iodophenyl)acetamide

Chemical Property:

• PSA: 44.08000
• LogP: 2.46870
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 260.96506
• Heavy Atom Count: 11
• Complexity: 141

Purity/Quality:

4-IODOPHENYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(=O)N)I

Technology Process of 2-(4-Iodophenyl)acetamide

There total 6 articles about 2-(4-Iodophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-iodophenylacetate (63349-52-0) → 4-iodophenylacetamide (84863-81-0)

Guidance literature:

With ammonia; In methanol; for 96h; Ambient temperature;

DOI:10.1021/jm00359a015

Reference yield: 78.0%

C24H23INO4Pol → 4-iodophenylacetamide (84863-81-0)

Guidance literature:

C₂₄H₂₃INO₄Pol; With potassium carbonate; phenylboronic acid; In ethanol; at 80 ℃; Inert atmosphere; solid phase reaction;

With trifluoroacetic acid; In dichloromethane; for 2h; Mechanism;

DOI:10.1002/adsc.201000820

Reference yield: 54.0%

iodobenzene (591-50-4) + C24H23INO4Pol + phenylboronic acid (98-80-6) → biphenyl (92-52-4,1594-86-1) + 4-iodophenylacetamide (84863-81-0) + 1,1-biphenyl-4-ylacetamide (63780-50-7)

Guidance literature:

iodobenzene; C₂₄H₂₃INO₄Pol; phenylboronic acid; With potassium carbonate; In ethanol; at 80 ℃; for 12h; Inert atmosphere; solid phase reaction;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Mechanism;

DOI:10.1002/adsc.201000820

upstream raw materials:

4-Iodoacetophenone

(4-iodophenyl)acetic acid

4-Iodobenzeneacetyl chloride

methyl 4-iodophenylacetate

Downstream raw materials:

(4-iodo-phenyl)-acetic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)

3-Hydroxy-4-(4-iodo-phenyl)-pyrrole-2,5-dione