63349-52-0

Basic information

• Product Name: 4-IODPHENYLACETIC ACID METHYL ESTER
• Synonyms: 4-IODPHENYLACETIC ACID METHYL ESTER;METHYL 4-IODOPHENYLACETATE;Benzeneacetic acid, 4-iodo-, Methyl ester;Methyl 2-(4-iodophenyl)acetate
• CAS NO: 63349-52-0
• Molecular Formula: C₉H₉IO₂
• Molecular Weight: 276.07103
• Mol File: 63349-52-0.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 271.9±15.0 °C(Predicted)
• Appearance: /
• Density: 1.680±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-IODPHENYLACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODPHENYLACETIC ACID METHYL ESTER(63349-52-0)
• EPA Substance Registry System: 4-IODPHENYLACETIC ACID METHYL ESTER(63349-52-0)

Safety Data

• Hazardous Substances Data: 63349-52-0(Hazardous Substances Data)

Usage

General Description

4-Iodphenylacetic acid methyl ester is a chemical compound with the molecular formula C9H9IO2. It is a methyl ester of 4-iodophenylacetic acid, and is commonly used in the field of organic synthesis. 4-IODPHENYLACETIC ACID METHYL ESTER is a white to off-white solid with a molecular weight of 292.07 g/mol. It is mainly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it can be used as a building block for the synthesis of various biologically active molecules. 4-Iodphenylacetic acid methyl ester is known for its potential applications in medicinal chemistry and drug discovery. Overall, it is a versatile compound with numerous uses in the chemical industry.

InChI:InChI=1S/C9H9IO2/c1-12-9(11)6-7-2-4-8(10)5-3-7/h2-5H,6H2,1H3

Upstream product

• 67-56-1 methanol 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 37051-38-0 4-Iodobenzeneacetyl chloride 
• 70290-37-8 (4-methylsulfanyl-phenyl)-acetic acid methyl ester 
• 74-88-4 methyl iodide 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 51628-12-7 4-iodophenylacetonitrile 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 13329-40-3 4-Iodoacetophenone 

Downstream Products

• 182500-80-7 2-(4-Iodo-phenyl)-butyric acid methyl ester 
• 182500-81-8 2-(4-Iodo-phenyl)-pentanoic acid methyl ester 
• 607714-18-1 {4-[8-formyl-2,2,4,4-tetramethyl chroman-6-ylethynyl]-phenyl}-acetic acid methyl ester 
• 345964-86-5 methyl {4-[4-(1-isopropoxycyclopropyl)-phenylethynyl]-phenyl}-acetate 
• 345965-10-8 methyl {4-[4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate 
• 345966-16-7 methyl {4-[(3-isopropyl-4-((1-methylcyclopropyl)oxymethyl)phenyl)ethynyl]phenyl}acetate 
• 345964-02-5 4-[(8,8-dimethyl-5-oxo-5,6,7,8-tetrahydronaphthalene-2-ylethynyl)-phenyl]-acetic acid methyl ester 
• 63349-53-1 methyl [p-(phenylthio)phenyl]acetate 
• 345965-41-5 methyl {4-[4-(1-ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-phenyl}-acetate 
• 1011486-70-6 C₁₅H₁₉N₃O₂ 
• 1191885-22-9 C₂₅H₁₈O₂ 
• 252752-46-8 methyl 2-(4-hydrazinylphenyl)acetate hydrochloride 
• 189131-92-8 methyl 4-(6-hydroxy-1-hexynyl)phenylacetate 
• 192804-73-2 methyl 4-(5-hydroxy-1-pentynyl)phenylacetate 

Relevant articles and documents

Syntheses of radioiodinated pyrimidine-2,4,6-triones as potential agents for non-invasive imaging of matrix metalloproteinases

Dysregulated expression or activation of matrix metalloproteinases (MMPs) is observed in many kinds of live-threatening diseases. Therefore, MMP imaging for example with radiolabelled MMP inhibitors (MMPIs) potentially represents a valuable tool for clinical diagnostics using non-invasive single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. This work includes the organic chemical syntheses and in vitro evaluation of five iodinated barbiturate based MMPIs and the selection of derivative 9 for radiosyntheses of isotopologues [123I]9 potentially useful for MMP SPECT imaging and [124I]9 for MMP PET imaging.

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides

An electrochemical method for the oxidative Z-selective C(sp2)-H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.