4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester

Base Information

• Chemical Name: 4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester
• CAS No.: 53241-92-2
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• Mol file: 53241-92-2.mol

Synonyms:4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester

Chemical Property of 4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester

Chemical Property:

• Melting Point: 274 °C
• PSA: 81.54000
• LogP: 1.52070
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-hydroxy-6-methoxy-1,5-naphthyridine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester

There total 11 articles about 4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diethyl {[(6-methoxypyridin-3-yl)amino]methylidene}propanedioate (53241-90-0) → 4-Hydroxy-6-methoxy-[1,5]naphthyridine-3-carboxylic Acid Ethyl Ester (53241-92-2)

Guidance literature:

With diphenylether; at 260 ℃; for 0.0833333h;

DOI:10.1021/ml500069w

Reference yield: 73.0%

diethyl {[(6-methoxypyridin-3-yl)amino]methylidene}propanedioate (53241-90-0) → ethyl 6-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (724788-63-0,53241-92-2)

Guidance literature:

With diphenyl ether-biphenyl eutectic; for 0.333333h; Heating / reflux;

Reference yield: 71.0%

6-methoxy-pyridin-3-ylamine (6628-77-9) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 4-Hydroxy-6-methoxy-[1,5]naphthyridine-3-carboxylic Acid Ethyl Ester (53241-92-2)

Guidance literature:

In ethanol; at 80 ℃; for 22h; Heating / reflux;

upstream raw materials:

diethyl {[(6-methoxypyridin-3-yl)amino]methylidene}propanedioate

6-methoxy-pyridin-3-ylamine

diethyl 2-ethoxymethylenemalonate

diethyl 2-(ethoxycarbonylmethylene)malonate

Downstream raw materials:

6-methoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid

ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate

C₂₈H₂₆F₂N₄O₃

C₂₇H₂₆F₂N₄O₃

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