BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-

Base Information

• Chemical Name: BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
• CAS No.: 1269055-85-7
• Molecular Formula: C15H13F2NO3
• Molecular Weight: 293.27
• Mol file: 1269055-85-7.mol

Synonyms:BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-;MUT056399;4-(4-Ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide

Chemical Property of BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-

Chemical Property:

• Boiling Point: 373.8±42.0 °C(Predicted)
• PKA: 8.93±0.48(Predicted)
• PSA: 72.55000
• Density: 1.342±0.06 g/cm3(Predicted)
• LogP: 3.82430

Purity/Quality:

97% ^*data from raw suppliers

MUT-056399 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-

There total 5 articles about BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(4-ethyl-5-fluoro-2-methoxy-phenoxy)-3-fluorobenzamide (1269055-92-6) → 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide (1269055-85-7)

Guidance literature:

4-(4-ethyl-5-fluoro-2-methoxy-phenoxy)-3-fluorobenzamide; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; at -20 ℃; Product distribution / selectivity;

Reference yield:

1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethanone (1065076-49-4) → 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide (1269055-85-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: zinc; acetic acid / 70 °C / Reflux

2.1: potassium hydroxide / acetonitrile / 16 h / Reflux; Inert atmosphere

3.1: trifluoroacetic acid; sulfuric acid / 1.5 h / Reflux

3.2: 20 °C / Cooling with ice

4.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

4.2: -20 °C

With sulfuric acid; boron tribromide; acetic acid; trifluoroacetic acid; potassium hydroxide; zinc; In dichloromethane; acetonitrile; 1.1: Clemmensen Reaction;

Reference yield:

4-ethyl-5-fluoroguaiacol (1065076-45-0) → 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide (1269055-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / acetonitrile / 16 h / Reflux; Inert atmosphere

2.1: trifluoroacetic acid; sulfuric acid / 1.5 h / Reflux

2.2: 20 °C / Cooling with ice

3.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3.2: -20 °C

With sulfuric acid; boron tribromide; trifluoroacetic acid; potassium hydroxide; In dichloromethane; acetonitrile;

upstream raw materials:

4-(4-ethyl-5-fluoro-2-methoxy-phenoxy)-3-fluorobenzamide

1-(2-fluoro-4-hydroxy-5-methoxyphenyl)ethanone

4-ethyl-5-fluoroguaiacol

5-fluoro-2-methoxy phenol

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